Literature DB >> 9809480

Role of intracellular calcium in peroxide-induced potentiation of norepinephrine release from bovine isolated irides.

C A Opere1, S E Ohia.   

Abstract

1. BAPTA AM (10 microM), thapsigargin (10 microM), ruthenium red (30 microM) and oligomycin (30 microM) inhibited field-stimulated [3H]NE release from bovine isolated irides by 54%, 30%, 30% and 26%, respectively. 2. Both BAPTA AM and thapsigargin had no significant effect (P>0.05) on H2O2-induced potentiation of evoked [3H]NE release. 3. Ruthenium red prevented (but oligomycin enhanced) H2O2-induced enhancement of evoked [3H]NE release. 4. We conclude that, although intracellular calcium participates in field-stimulation evoked [3H]NE release from bovine isolated irides, only the mitochondrial pool of calcium may be involved in peroxide-induced enhancement of sympathetic neurotransmission.

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Year:  1998        PMID： 9809480     DOI： 10.1016/s0306-3623(98)00090-1

Source DB:  PubMed          Journal:  Gen Pharmacol        ISSN： 0306-3623


  3 in total

1.  Effect of inhibition of cyclooxygenase on pre- and postjunctional actions of peroxides in the iris-ciliary body.

Authors:  J Graham; S O Awe; A M LeDay; J C Rice; G Ramos; L C Harris; C A Opere; S E Ohia
Journal:  Neurochem Res       Date:  2000-04       Impact factor: 3.996

2.  Effect of peroxides on [3H]D-aspartate release from bovine isolated retinae.

Authors:  Angela M LeDay; Sunday O Awe; Kaustubh Kulkarni; Lydia C Harris; Catherine Opere; Alekha Dash; Sunny E Ohia
Journal:  Neurochem Res       Date:  2004-04       Impact factor: 3.996

3.  Pharmacological Actions of Hydrogen Sulfide Donors on Sympathetic Neurotransmission in the Bovine Anterior Uvea, In Vitro.

Authors:  Ankita Salvi; Pratik Bankhele; Jamal M Jamil; Madhura Kulkarni-Chitnis; Ya Fatou Njie-Mbye; Sunny E Ohia; Catherine A Opere
Journal:  Neurochem Res       Date:  2015-12-23       Impact factor: 3.996
  3 in total

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