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Literature DB >> 9809303

Viruses as transneuronal tracers for defining neural circuits.

Abstract

Live viruses can be used as tools to label chains of neurons and thus to define functionally connected CNS circuits. This review summarizes the background and general principles involved in using the viral tracing technology. An attenuated form of a pig herpes virus, known as the Bartha's K strain of pseudorabies virus, has proven to be a useful type of virus for the analysis of CNS systems in the rat. The properties of this virus and the evidence for its specificity in causing trans-synaptic infections is discussed.

Entities: Species

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Year: 1998 PMID： 9809303 DOI： 10.1016/s0149-7634(98)00006-2

Source DB: PubMed Journal: Neurosci Biobehav Rev ISSN： 0149-7634 Impact factor: 8.989

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Cited

24 in total

1. Intravitreal injection of the attenuated pseudorabies virus PRV Bartha results in infection of the hamster suprachiasmatic nucleus only by retrograde transsynaptic transport via autonomic circuits.

Authors: Gary E Pickard; Cynthia A Smeraski; Christine C Tomlinson; Bruce W Banfield; Jessica Kaufman; Christine L Wilcox; Lynn W Enquist; Patricia J Sollars
Journal: J Neurosci Date: 2002-04-01 Impact factor: 6.167

Viruses as transneuronal tracers for defining neural circuits.

1. Intravitreal injection of the attenuated pseudorabies virus PRV Bartha results in infection of the hamster suprachiasmatic nucleus only by retrograde transsynaptic transport via autonomic circuits.

Review 2. Neural Control of Energy Expenditure.

Review 3. Auditory brainstem circuits that mediate the middle ear muscle reflex.

4. Phenotypic traits of the hypothalamic PVN cells innervating airway-related vagal preganglionic neurons.

5. Complexity and anisotropy in host morphology make populations less susceptible to epidemic outbreaks.

6. Transneuronal circuit analysis with pseudorabies viruses.

7. Serotonergic projections from the caudal raphe nuclei to the hypoglossal nucleus in male and female rats.

Review 8. The alpha-herpesviruses: molecular pathfinders in nervous system circuits.

Review 9. Quintessential risk factors: their role in promoting cognitive dysfunction and Alzheimer's disease.

10. Fluorescence-based monitoring of in vivo neural activity using a circuit-tracing pseudorabies virus.