| Literature DB >> 9809063 |
J D Leverson1, P J Koskinen, F C Orrico, E M Rainio, K J Jalkanen, A B Dash, R N Eisenman, S A Ness.
Abstract
The pim-1 oncogene is regulated by hematopoietic cytokine receptors, encodes a serine/threonine protein kinase, and cooperates with c-myc in lymphoid cell transformation. Using a yeast two-hybrid screen, we found that Pim-1 protein binds to p100, a transcriptional coactivator that interacts with the c-Myb transcription factor. Pim-1 phosphorylated p100 in vitro, formed a stable complex with p100 in animal cells, and functioned downstream of Ras to stimulate c-Myb transcriptional activity in a p100-dependent manner. Thus, Pim-1 and p100 appear to be components of a novel signal transduction pathway affecting c-Myb activity, linking all three to the cytokine-regulated control of hematopoietic cell growth, differentiation, and apoptosis.Entities:
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Year: 1998 PMID： 9809063 DOI： 10.1016/s1097-2765(00)80141-0
Source DB: PubMed Journal: Mol Cell ISSN： 1097-2765 Impact factor: 17.970