Literature DB >> 9807840

Signal-transduction cascades as targets for therapeutic intervention by natural products.

M E Cardenas1, A Sanfridson, N S Cutler, J Heitman.   

Abstract

Many bacteria and fungi produce natural products that are toxic to other microorganisms and have a variety of physiological effects in animals. Recent studies have revealed that, in several cases, the targets of these agents are components of conserved signal-transduction cascades. This article looks at the mechanisms of action of five natural products--the immunosuppressants cyclosporin A, FK506 and rapamycin, and the antiproliferative agents wortmannin and geldanamycin. These mechanisms reveal the importance of signal-transduction cascades as targets for therapeutic intervention and the enormous utility of studies of natural-product action in simple model genetic systems.

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Year:  1998        PMID： 9807840     DOI： 10.1016/s0167-7799(98)01239-6

Source DB:  PubMed          Journal:  Trends Biotechnol        ISSN： 0167-7799            Impact factor:   19.536


  21 in total

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