N Sutcliffe1, M Inanc, P Speight, D Isenberg. 1. Centre for Rheumatology/Bloomsbury Rheumatology Unit, Department of Medicine, University College London.
Abstract
OBJECTIVE: To determine the clinical and laboratory predictors of lymphoma development in primary Sjögren's syndrome (pSS). METHODS: Seventy-two patients with pSS were studied. Demographic data, clinical features, serum gamma-globulin levels, autoantibodies, and HLA status were reviewed. For statistical analysis, Mann-Whitney U-test, Fisher's exact test, logistic regression analysis, Kaplan-Meier method, and log-rank tests were applied. RESULTS: Five patients developed a distinct non-Hodgkin's lymphoma of mucosa-associated lymphoid tissue (MALT). A history of swollen salivary glands, lymphadenopathy, and leg ulcers predicted lymphoma development. CONCLUSION: Patients with pSS are at increased risk of lymphoma development, and those who have the above risk factors must be carefully observed.
OBJECTIVE: To determine the clinical and laboratory predictors of lymphoma development in primary Sjögren's syndrome (pSS). METHODS: Seventy-two patients with pSS were studied. Demographic data, clinical features, serum gamma-globulin levels, autoantibodies, and HLA status were reviewed. For statistical analysis, Mann-Whitney U-test, Fisher's exact test, logistic regression analysis, Kaplan-Meier method, and log-rank tests were applied. RESULTS: Five patients developed a distinct non-Hodgkin's lymphoma of mucosa-associated lymphoid tissue (MALT). A history of swollen salivary glands, lymphadenopathy, and leg ulcers predicted lymphoma development. CONCLUSION:Patients with pSS are at increased risk of lymphoma development, and those who have the above risk factors must be carefully observed.
Authors: Maria I Christodoulou; Efstathia K Kapsogeorgou; Niki M Moutsopoulos; Haralampos M Moutsopoulos Journal: Am J Pathol Date: 2008-09-25 Impact factor: 4.307
Authors: A Keszler; L I Adler; M S Gandolfo; P A Masquijo Bisio; A C Smith; C F Vollenweider; A M Heidenreich; G de Stefano; M V Kambo; D P Cox; M Narbaitz; H E Lanfranchi Journal: Oral Surg Oral Med Oral Pathol Oral Radiol Date: 2012-11-13