OBJECTIVE: To estimate the survival of men with familial prostate cancer and compare them with prostate cancer cases unselected for family history. PATIENTS AND METHODS: The overall and prostate cancer-specific survival was calculated in two large (249 and 304 men, respectively) population-based cohorts of men with familial prostate cancer. The tumour grade at diagnosis was also obtained in one of the cohorts. RESULTS: There were no significant differences in either overall or prostate cancer-specific survival between familial and sporadic cases. The spectrum of tumour grades at diagnosis in familial cases did not differ from that in a population with prostate cancer unselected for family history. CONCLUSION: No differences in treatment between men with or without a positive family history of prostate cancer are justified, based on the result from this study.
OBJECTIVE: To estimate the survival of men with familial prostate cancer and compare them with prostate cancer cases unselected for family history. PATIENTS AND METHODS: The overall and prostate cancer-specific survival was calculated in two large (249 and 304 men, respectively) population-based cohorts of men with familial prostate cancer. The tumour grade at diagnosis was also obtained in one of the cohorts. RESULTS: There were no significant differences in either overall or prostate cancer-specific survival between familial and sporadic cases. The spectrum of tumour grades at diagnosis in familial cases did not differ from that in a population with prostate cancer unselected for family history. CONCLUSION: No differences in treatment between men with or without a positive family history of prostate cancer are justified, based on the result from this study.
Authors: Ruben Cremers; Christi van Asperen; Paul Kil; Hans Vasen; Tjerk Wiersma; Inge van Oort; Lambertus Kiemeney Journal: Fam Cancer Date: 2012-06 Impact factor: 2.375
Authors: Ruben G Cremers; Katja K Aben; Inge M van Oort; J P Michiel Sedelaar; Hans F Vasen; Sita H Vermeulen; Lambertus A Kiemeney Journal: Prostate Date: 2016-03-14 Impact factor: 4.104
Authors: Elena Castro; Chee Goh; David Olmos; Ed Saunders; Daniel Leongamornlert; Malgorzata Tymrakiewicz; Nadiya Mahmud; Tokhir Dadaev; Koveela Govindasami; Michelle Guy; Emma Sawyer; Rosemary Wilkinson; Audrey Ardern-Jones; Steve Ellis; Debra Frost; Susan Peock; D Gareth Evans; Marc Tischkowitz; Trevor Cole; Rosemarie Davidson; Diana Eccles; Carole Brewer; Fiona Douglas; Mary E Porteous; Alan Donaldson; Huw Dorkins; Louise Izatt; Jackie Cook; Shirley Hodgson; M John Kennedy; Lucy E Side; Jacqueline Eason; Alex Murray; Antonis C Antoniou; Douglas F Easton; Zsofia Kote-Jarai; Rosalind Eeles Journal: J Clin Oncol Date: 2013-04-08 Impact factor: 44.544