| Literature DB >> 9804551 |
M J Gardner1, H Tettelin, D J Carucci, L M Cummings, L Aravind, E V Koonin, S Shallom, T Mason, K Yu, C Fujii, J Pederson, K Shen, J Jing, C Aston, Z Lai, D C Schwartz, M Pertea, S Salzberg, L Zhou, G G Sutton, R Clayton, O White, H O Smith, C M Fraser, M D Adams, J C Venter, S L Hoffman.
Abstract
Chromosome 2 of Plasmodium falciparum was sequenced; this sequence contains 947,103 base pairs and encodes 210 predicted genes. In comparison with the Saccharomyces cerevisiae genome, chromosome 2 has a lower gene density, introns are more frequent, and proteins are markedly enriched in nonglobular domains. A family of surface proteins, rifins, that may play a role in antigenic variation was identified. The complete sequencing of chromosome 2 has shown that sequencing of the A+T-rich P. falciparum genome is technically feasible.Entities:
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Year: 1998 PMID： 9804551 DOI： 10.1126/science.282.5391.1126
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728