| Literature DB >> 9804127 |
C Kawanishi1, Y Shimoda, J Fujimaki, H Onishi, K Suzuki, T Hanihara, N Sugiyama, K Kosaka.
Abstract
Cytochrome P450IID6 (CYP2D6) plays an important role in the hepatic metabolism of various psychotropic drugs. We detected a mutation of the CYP2D6 gene in two patients who previously had episodes of neuroleptic malignant syndrome (NMS). They were homozygous for a mutated CYP2D6J allele conferring a poor-metabolizer phenotype. Possession of this trait may contribute to susceptibility to NMS.Entities:
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Year: 1998 PMID： 9804127 DOI： 10.1016/s0022-510x(98)00238-x
Source DB: PubMed Journal: J Neurol Sci ISSN： 0022-510X Impact factor: 3.181