Literature DB >> 9804040

2-[18F]Fluoro-A-85380, an in vivo tracer for the nicotinic acetylcholine receptors.

A G Horti1, U Scheffel, A O Koren, H T Ravert, W B Mathews, J L Musachio, P A Finley, E D London, R F Dannals.   

Abstract

The in vivo brain regional distribution of 2-[18F]fluoro-A-85380, a novel tracer for positron emission tomographic (PET) studies, followed the regional densities of brain nAChRs reported in the literature. Evidence of binding to nAChRs and high specificity of the binding in vivo was demonstrated by inhibition with nAChR selective ligands as well as with unlabeled 2-fluoro-A-85380. A preliminary toxicology study of the 2-fluoro-A-85380 showed a relatively low biological effect. 2-[18F]Fluoro-A-85380 holds promise as a useful radiotracer for imaging of nAChRs with PET.

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Year:  1998        PMID： 9804040     DOI： 10.1016/s0969-8051(98)00031-6

Source DB:  PubMed          Journal:  Nucl Med Biol        ISSN： 0969-8051            Impact factor:   2.408


  15 in total

1.  Quantitative Molecular Imaging of Neuronal Nicotinic Acetylcholine Receptors in the Human Brain with A-85380 Radiotracers.

Authors:  Shahrdad Lotfipour; Mark Mandelkern; Arthur L Brody
Journal:  Curr Med Imaging Rev       Date:  2011-05-01

2.  Quantification of nicotinic acetylcholine receptors in the human brain with PET: bolus plus infusion administration of 2-[18F]F-A85380.

Authors:  Alane S Kimes; Svetlana I Chefer; John A Matochik; Carlo S Contoreggi; D Bruce Vaupel; Elliot A Stein; Alexey G Mukhin
Journal:  Neuroimage       Date:  2007-09-19       Impact factor: 6.556

3.  Impact of short access nicotine self-administration on expression of α4β2* nicotinic acetylcholine receptors in non-human primates.

Authors:  Bernard Le Foll; Svetlana I Chefer; Alane S Kimes; Elliot A Stein; Steven R Goldberg; Alexey G Mukhin
Journal:  Psychopharmacology (Berl)       Date:  2016-02-25       Impact factor: 4.530

Review 4.  Radiosyntheses using fluorine-18: the art and science of late stage fluorination.

Authors:  Erin L Cole; Megan N Stewart; Ryan Littich; Raphael Hoareau; Peter J H Scott
Journal:  Curr Top Med Chem       Date:  2014       Impact factor: 3.295

5.  Effect of secondhand smoke on occupancy of nicotinic acetylcholine receptors in brain.

Authors:  Arthur L Brody; Mark A Mandelkern; Edythe D London; Aliyah Khan; Daniel Kozman; Matthew R Costello; Evan E Vellios; Meena M Archie; Rebecca Bascom; Alexey G Mukhin
Journal:  Arch Gen Psychiatry       Date:  2011-05-02

Review 6.  Functional brain imaging of tobacco use and dependence.

Authors:  Arthur L Brody
Journal:  J Psychiatr Res       Date:  2005-06-24       Impact factor: 4.791

Review 7.  In vivo brain imaging of human exposure to nicotine and tobacco.

Authors:  Anil Sharma; Arthur L Brody
Journal:  Handb Exp Pharmacol       Date:  2009

8.  Baseline expression of alpha4beta2* nicotinic acetylcholine receptors predicts motivation to self-administer nicotine.

Authors:  Bernard Le Foll; Svetlana I Chefer; Alane S Kimes; Dean Shumway; Elliot A Stein; Alexey G Mukhin; Steven R Goldberg
Journal:  Biol Psychiatry       Date:  2008-12-18       Impact factor: 13.382

9.  Greater nicotinic acetylcholine receptor density in smokers than in nonsmokers: a PET study with 2-18F-FA-85380.

Authors:  Alexey G Mukhin; Alane S Kimes; Svetlana I Chefer; John A Matochik; Carlo S Contoreggi; Andrew G Horti; D Bruce Vaupel; Olga Pavlova; Elliot A Stein
Journal:  J Nucl Med       Date:  2008-09-15       Impact factor: 10.057

Review 10.  Acetylcholine receptors in dementia and mild cognitive impairment.

Authors:  Osama Sabri; Kai Kendziorra; Henrike Wolf; Hermann-Josef Gertz; Peter Brust
Journal:  Eur J Nucl Med Mol Imaging       Date:  2008-03       Impact factor: 9.236
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