Literature DB >> 9801816

Endothelin receptor antagonists: synthesis and structure-activity relationships of substituted benzothiazine-1,1-dioxides.

K A Berryman1, J J Edmunds, A M Bunker, S Haleen, J Bryant, K M Welch, A M Doherty.   

Abstract

The development of benzothiazine-1,1-dioxide derivatives as a new structural class of potent endothelin receptor antagonists is described. Structure-activity relationships (SAR) revealed that PD164800 (1) is a potent antagonist of the ETA receptor subtype.

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Year:  1998        PMID： 9801816     DOI： 10.1016/s0968-0896(98)00080-7

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  2 in total

1.  3-(3-Chloro-benzo-yl)-4-hydr-oxy-2H-1,2-benzothia-zine 1,1-dioxide.

Authors:  Zunera Khalid; Hamid Latif Siddiqui; Matloob Ahmad; Sana Aslam; Masood Parvez
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-03-20

2.  Synthesis and α-Glucosidase Inhibition Activity of 2-[3-(Benzoyl/4-bromobenzoyl)-4-hydroxy-1,1-dioxido-2H-benzo[e][1,2]thiazin-2-yl]-N-arylacetamides: An In Silico and Biochemical Approach.

Authors:  Furqan Ahmad Saddique; Sana Aslam; Matloob Ahmad; Usman Ali Ashfaq; Muhammad Muddassar; Sadia Sultan; Saman Taj; Muzammil Hussain; Dae Sung Lee; Magdi E A Zaki
Journal:  Molecules       Date:  2021-05-20       Impact factor: 4.411
  2 in total

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