Literature DB >> 9801814

2-Azetidinone cholesterol absorption inhibitors: increased potency by substitution of the C-4 phenyl ring.

W D Vaccaro1, R Sher, H R Davis.   

Abstract

SAR studies directed towards the optimization of 2-azetidinone cholesterol absorption inhibitors led to the discovery of 11a, the most potent cholesterol absorption inhibitor yet identified.

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Year:  1998        PMID： 9801814     DOI： 10.1016/s0968-0896(98)00073-x

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  1 in total

1.  Synthesis and Biological Evaluation of Ezetimibe Analogs as Possible Cholesterol Absorption Inhibitors.

Authors:  Yubin Wang; Wenlong Huang; Huibin Zhang; Jinpei Zhou
Journal:  Lett Drug Des Discov       Date:  2011-07       Impact factor: 1.150
  1 in total

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