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Literature DB >> 9798732

Inhibitory effects of Serenoa repens on the kinetic of pig prostatic microsomal 5alpha-reductase activity.

M F Palin¹, M Faguy, J G LeHoux, G Pelletier.

Abstract

The pathogenesis of benign prostatic hyperplasia is linked to the accumulation of dihydrotestosterone (DHT), the active form of testosterone (T), in prostatic tissue. We have defined characteristics of 5alpha-reductase enzyme which catalyzes the conversion of T into DHT in prostatic microsomes of growing pigs. Peaks for the 5alpha-reductase activity were found at pH 5.5 and 8.0, which indicates the presence of both type 1 and type 2 isozymes. Kinetic parameters of porcine 5alpha-reductase in the presence of Serenoa repens extracts revealed uncompetitive, noncompetitive, and mixed types of inhibitions. Our results show the inhibitory action of S. repens on prostate porcine microsomal 5alpha-reductase activity.

Entities: Chemical

Mesh：

Substances：

Year: 1998 PMID： 9798732 DOI： 10.1385/ENDO:9:1:65

Source DB: PubMed Journal: Endocrine ISSN： 1355-008X Impact factor: 3.925

33 in total

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3 in total