| Literature DB >> 9794820 |
Abstract
Combinatorial regulation of eukaryotic transcription is mediated by proteins that associate in a specific manner to form multiprotein DNA-bound complexes. Substantial progress has recently been made towards the understanding of the molecular determinants of the protein-protein and protein-DNA interactions that govern assembly of these complexes. Three-dimensional structures have been determined of the MATalpha2/MCM1-DNA complex, the p50/p65 Rel homology domain heterodimer bound to DNA, the NFAT/Fos-Jun/DNA quaternary complex, and of the GABPalpha/beta ETS domain-ankyrin repeat heterodimer bound to DNA.Entities:
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Year: 1998 PMID: 9794820 DOI: 10.1016/s0959-437x(98)80010-5
Source DB: PubMed Journal: Curr Opin Genet Dev ISSN: 0959-437X Impact factor: 5.578