| Literature DB >> 9794195 |
T Taniguchi1, H Tsukada, H Nakamura, M Kodama, K Fukuda, T Saito, M Miyasaka, Y Seino.
Abstract
Increased expression of intercellular adhesion molecule-1 (ICAM-1) in the colon of inflammatory bowel disease (IBD) has been reported. We evaluated the effects of monoclonal antibodies to ICAM-1 on acute colitis induced by dextran sodium sulphate (DSS) in rats. Colitis was induced by feeding rats 3% DSS for 7 days. Anti-ICAM-1 antibody or vehicle alone was injected intraperitoneally in rats daily from day 0 to day 6. On day 7 the rats were killed and colitis was evaluated histologically. Prophylactic treatment with anti-ICAM-1 significantly attenuated colonic damage, neutrophil infiltration and the shortening of the colon in DSS colitis. Our findings demonstrate that ICAM-1 plays an important role in this model of inflammatory bowel disease. Although this study does not directly address the effect of anti-ICAM-1 therapy in IBD, our findings encourage experiments using therapies that target ICAM-1 in rats with already developed disease.Entities:
Mesh：
Substances：
Year: 1998 PMID： 9794195 DOI： 10.1111/j.1440-1746.1998.tb00766.x
Source DB: PubMed Journal: J Gastroenterol Hepatol ISSN： 0815-9319 Impact factor: 4.029