PURPOSE: Although both sevoflurane and isoflurane are thought to be less hepatotoxic than halothane or enflurane, recent case reports have described liver injury after sevoflurane or isoflurane anaesthesia. There are no studies comparing liver function after sevoflurane or isoflurane anaesthesia. The purpose of this study was to compare serum liver enzyme concentrations in patients receiving either sevoflurane or isoflurane anaesthesia prospectively. METHODS: Ninety patients scheduled for elective neurosurgery were studied. Serum concentrations of aspartame aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin (TBil), alkaline phosphatase (ALP), gamma-glutamyl transpeptidase (GTP), and lactate dehydrogenase (LDH) were measured before and, 1, 2, 3, 7, and 14 days after either sevoflurane (45 patients) or isoflurane (45 patients) anaesthesia. RESULTS: AST, ALT and GTP increased peaking seven days after anaesthesia, especially in the isoflurane group. The numbers of patients with abnormal values in AST and ALT were not different in the isoflurane from that in the sevoflurane group. The increase in TBil peaked one day after anaesthesia in both groups. CONCLUSION: Even in a small number of patients, isoflurane induced an elevation of serum levels of liver enzymes more frequently than did sevoflurane three to 14 days after anaesthesia.
PURPOSE: Although both sevoflurane and isoflurane are thought to be less hepatotoxic than halothane or enflurane, recent case reports have described liver injury after sevoflurane or isoflurane anaesthesia. There are no studies comparing liver function after sevoflurane or isoflurane anaesthesia. The purpose of this study was to compare serum liver enzyme concentrations in patients receiving either sevoflurane or isoflurane anaesthesia prospectively. METHODS: Ninety patients scheduled for elective neurosurgery were studied. Serum concentrations of aspartame aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin (TBil), alkaline phosphatase (ALP), gamma-glutamyl transpeptidase (GTP), and lactate dehydrogenase (LDH) were measured before and, 1, 2, 3, 7, and 14 days after either sevoflurane (45 patients) or isoflurane (45 patients) anaesthesia. RESULTS: AST, ALT and GTP increased peaking seven days after anaesthesia, especially in the isoflurane group. The numbers of patients with abnormal values in AST and ALT were not different in the isoflurane from that in the sevoflurane group. The increase in TBil peaked one day after anaesthesia in both groups. CONCLUSION: Even in a small number of patients, isoflurane induced an elevation of serum levels of liver enzymes more frequently than did sevoflurane three to 14 days after anaesthesia.
Authors: Kazufumi Shimazutsu; Kenichiro Uemura; Kathryn M Auten; Matthew F Baldwin; Samuel W Belknap; Francisco La Banca; Maximilian C Jones; Deborah J McClaine; Rebecca J McClaine; W Steve Eubanks; Jonathan S Stamler; James D Reynolds Journal: Clin Transl Sci Date: 2009-12 Impact factor: 4.689
Authors: Oliver A Cornely; José M Cisneros; Julian Torre-Cisneros; María Jesús Rodríguez-Hernández; Luis Tallón-Aguilar; Esther Calbo; Juan P Horcajada; Christian Queckenberg; Ulrike Zettelmeyer; Dorothee Arenz; Clara M Rosso-Fernández; Silvia Jiménez-Jorge; Guy Turner; Susan Raber; Seamus O'Brien; Alison Luckey Journal: J Antimicrob Chemother Date: 2020-03-01 Impact factor: 5.790
Authors: Carlos Chaccour; Gloria Abizanda; Ángel Irigoyen-Barrio; Aina Casellas; Azucena Aldaz; Fernando Martínez-Galán; Felix Hammann; Ana Gloria Gil Journal: Sci Rep Date: 2020-10-13 Impact factor: 4.379