Literature DB >> 9792613

Pituitary adenylate cyclase-activating polypeptide-nerve terminals densely innervate corticotropin-releasing hormone-neurons in the hypothalamic paraventricular nucleus of the rat.

G Légrádi1, J Hannibal, R M Lechan.   

Abstract

Pituitary adenylate cyclase-activating polypeptide (PACAP) is widely distributed in many regions of the hypothalamus including the paraventricular nucleus (PVN). In this study, using well-characterized antibodies against PACAP and corticotropin-releasing hormone (CRH), we identified numerous nerve fibers with PACAP-immunoreactivity (ir) closely apposed to CRH neurons in the medial parvocellular subdivision of the rat PVN. Electron microscopy revealed the presence of synapses between PACAP-ir containing terminals and CRH-perikarya and -dendrites. These morphological observations suggest that PACAP may modulate the activation of the hypothalamic-pituitary-adrenal axis.

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Year:  1998        PMID： 9792613     DOI： 10.1016/s0304-3940(98)00255-9

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  29 in total

1.  Pituitary adenylyl cyclase-activating polypeptide stimulates DNA synthesis but delays maturation of oligodendrocyte progenitors.

Authors:  M Lee; V Lelievre; P Zhao; M Torres; W Rodriguez; J Y Byun; S Doshi; Y Ioffe; G Gupta; A E de los Monteros; J de Vellis; J Waschek
Journal:  J Neurosci       Date:  2001-06-01       Impact factor: 6.167

2.  Stimulation of the hypothalamic ventromedial nuclei by pituitary adenylate cyclase-activating polypeptide induces hypophagia and thermogenesis.

Authors:  Jon M Resch; Joanne P Boisvert; Allison E Hourigan; Christopher R Mueller; Sun Shin Yi; Sujean Choi
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2011-09-28       Impact factor: 3.619

3.  Rapgef2 connects GPCR-mediated cAMP signals to ERK activation in neuronal and endocrine cells.

Authors:  Andrew C Emery; Maribeth V Eiden; Tomris Mustafa; Lee E Eiden
Journal:  Sci Signal       Date:  2013-06-25       Impact factor: 8.192

Review 4.  Pituitary adenylate cyclase activating polypeptide (PACAP), stress, and sex hormones.

Authors:  S Bradley King; Donna J Toufexis; Sayamwong E Hammack
Journal:  Stress       Date:  2017-06-14       Impact factor: 3.493

Review 5.  Pituitary adenylate cyclase activating polypeptide in stress-related disorders: data convergence from animal and human studies.

Authors:  Sayamwong E Hammack; Victor May
Journal:  Biol Psychiatry       Date:  2014-12-09       Impact factor: 13.382

Review 6.  Neuroendocrine pathways underlying risk and resilience to PTSD in women.

Authors:  Meghna Ravi; Jennifer S Stevens; Vasiliki Michopoulos
Journal:  Front Neuroendocrinol       Date:  2019-09-19       Impact factor: 8.606

7.  PACAP-deficient mice show attenuated corticosterone secretion and fail to develop depressive behavior during chronic social defeat stress.

Authors:  Michael L Lehmann; Tomris Mustafa; Adrian M Eiden; Miles Herkenham; Lee E Eiden
Journal:  Psychoneuroendocrinology       Date:  2012-10-11       Impact factor: 4.905

8.  Chronic stress increases pituitary adenylate cyclase-activating peptide (PACAP) and brain-derived neurotrophic factor (BDNF) mRNA expression in the bed nucleus of the stria terminalis (BNST): roles for PACAP in anxiety-like behavior.

Authors:  Sayamwong E Hammack; Joseph Cheung; Kimberly M Rhodes; Kristin C Schutz; William A Falls; Karen M Braas; Victor May
Journal:  Psychoneuroendocrinology       Date:  2009-01-31       Impact factor: 4.905

9.  Pituitary adenylate cyclase-activating polypeptide stimulates glucose production via the hepatic sympathetic innervation in rats.

Authors:  Chun-Xia Yi; Ning Sun; Mariette T Ackermans; Anneke Alkemade; Ewout Foppen; Jing Shi; Mireille J Serlie; Ruud M Buijs; Eric Fliers; Andries Kalsbeek
Journal:  Diabetes       Date:  2010-03-31       Impact factor: 9.461

10.  Stress hormone synthesis in mouse hypothalamus and adrenal gland triggered by restraint is dependent on pituitary adenylate cyclase-activating polypeptide signaling.

Authors:  N Stroth; L E Eiden
Journal:  Neuroscience       Date:  2009-11-18       Impact factor: 3.590
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