STUDY OBJECTIVES: To determine the possible association of Chlamydia pneumoniae infection with diffuse panbronchiolitis (DPB) and with COPD. DESIGN: Prospective case-control study. SETTING: Division of Respiratory Diseases, Kawasaki Medical School Hospital. PARTICIPANTS: Fifteen DPB and 77 COPD patients who had acute exacerbations of respiratory conditions and 35 and 120 control subjects, respectively, matched for age, sex, and smoking status. MEASUREMENTS AND RESULTS: Nasopharyngeal swabs and paired serum samples were obtained from all patients and control subjects for isolation and antibody testing of C pneumoniae. C pneumoniae was isolated from one DPB patient and from no COPD patients or control subjects. Serologic evidence of acute C pneumoniae infection was observed in one DPB patient (6.7%) and six COPD patients (7.8%). The prevalence and mean titer of C pneumoniae IgG and IgA antibodies were significantly higher in COPD patients than in control subjects (p<0.001). However, no such differences were observed between DPB patients and control subjects. CONCLUSIONS: This study showed that C pneumoniae infection may be associated with acute exacerbations of COPD and that chronic C pneumoniae infection is common in COPD but not in DPB.
STUDY OBJECTIVES: To determine the possible association of Chlamydia pneumoniae infection with diffuse panbronchiolitis (DPB) and with COPD. DESIGN: Prospective case-control study. SETTING: Division of Respiratory Diseases, Kawasaki Medical School Hospital. PARTICIPANTS: Fifteen DPB and 77 COPDpatients who had acute exacerbations of respiratory conditions and 35 and 120 control subjects, respectively, matched for age, sex, and smoking status. MEASUREMENTS AND RESULTS: Nasopharyngeal swabs and paired serum samples were obtained from all patients and control subjects for isolation and antibody testing of C pneumoniae. C pneumoniae was isolated from one DPB patient and from no COPDpatients or control subjects. Serologic evidence of acute C pneumoniae infection was observed in one DPB patient (6.7%) and six COPDpatients (7.8%). The prevalence and mean titer of C pneumoniae IgG and IgA antibodies were significantly higher in COPDpatients than in control subjects (p<0.001). However, no such differences were observed between DPB patients and control subjects. CONCLUSIONS: This study showed that C pneumoniae infection may be associated with acute exacerbations of COPD and that chronic C pneumoniae infection is common in COPD but not in DPB.
Authors: Chi Young Jung; Yeoung Hun Choe; Sang Yeub Lee; Woo Jin Kim; Jong Deog Lee; Seung Won Ra; Eu Gene Choi; Jae Seung Lee; Myung Jae Park; Ju Ock Na Journal: Korean J Intern Med Date: 2018-06-25 Impact factor: 2.884
Authors: Marek Smieja; Richard Leigh; Astrid Petrich; Sylvia Chong; Dennis Kamada; Frederick E Hargreave; Charles H Goldsmith; Max Chernesky; James B Mahony Journal: BMC Infect Dis Date: 2002-07-05 Impact factor: 3.090