Literature DB >> 9790981

Establishment of the enzyme-linked immunosorbent assay for connective tissue growth factor (CTGF) and its detection in the sera of biliary atresia.

T Tamatani1, H Kobayashi, K Tezuka, S Sakamoto, K Suzuki, T Nakanishi, M Takigawa, T Miyano.   

Abstract

Connective tissue growth factor (CTGF) is a mitogenic, chemotactic, and cell matrix-inducing factor for fibroblasts. We generated murine monoclonal antibodies against CTGF and established a sandwich enzyme-linked immunosorbent assay (ELISA) for detection of CTGF. By using the ELISA, we confirmed that CTGF was specifically induced in human fibroblasts by TGF-beta but not by PDGF, FGF, IGF-I, or EGF. We also found that the serum levels of CTGF were significantly correlated with the progression of hepatic fibrosis in biliary atresia. These results indicated that CTGF is potentially a useful parameter for monitoring certain types of fibrotic disorders. Copyright 1998 Academic Press.

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Year:  1998        PMID： 9790981     DOI： 10.1006/bbrc.1998.9543

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  22 in total

1.  Hammerhead ribozyme-mediated knockdown of mRNA for fibrotic growth factors: transforming growth factor-beta 1 and connective tissue growth factor.

Authors:  Paulette M Robinson; Timothy D Blalock; Rong Yuan; Alfred S Lewin; Gregory S Schultz
Journal:  Methods Mol Biol       Date:  2012

2.  Serum interleukin-8 in children with biliary atresia: relationship with disease stage and biochemical parameters.

Authors:  Sittisak Honsawek; Voranush Chongsrisawat; Paisarn Vejchapipat; Nutchanart Thawornsuk; Pisit Tangkijvanich; Yong Poovorawan
Journal:  Pediatr Surg Int       Date:  2004-12-24       Impact factor: 1.827

3.  Susceptibility to liver fibrosis in mice expressing a connective tissue growth factor transgene in hepatocytes.

Authors:  Zhenyue Tong; Ruju Chen; Daniel S Alt; Sherri Kemper; Bernard Perbal; David R Brigstock
Journal:  Hepatology       Date:  2009-09       Impact factor: 17.425

4.  Catabolic effects of FGF-1 on chondrocytes and its possible role in osteoarthritis.

Authors:  Abdellatif El-Seoudi; Tarek Abd El Kader; Takashi Nishida; Takanori Eguchi; Eriko Aoyama; Masaharu Takigawa; Satoshi Kubota
Journal:  J Cell Commun Signal       Date:  2017-03-25       Impact factor: 5.782

5.  BMP9 inhibits the bone metastasis of breast cancer cells by downregulating CCN2 (connective tissue growth factor, CTGF) expression.

Authors:  Wei Ren; Xiaoxiao Sun; Ke Wang; Honglei Feng; Yuehong Liu; Chang Fei; Shaoheng Wan; Wei Wang; Jinyong Luo; Qiong Shi; Min Tang; Guowei Zuo; Yaguang Weng; Tongchuan He; Yan Zhang
Journal:  Mol Biol Rep       Date:  2014-01-12       Impact factor: 2.316

6.  The clinical value of serum connective tissue growth factor in the assessment of liver fibrosis.

Authors:  Dai Zhang; Nian-Yue Wang; Cheng-Bao Yang; Guo-Xiang Fang; Wei Liu; Jian Wen; Chan Luo
Journal:  Dig Dis Sci       Date:  2009-03-18       Impact factor: 3.199

7.  Transforming growth factor-beta1 (TGFbeta1) stimulates connective tissue growth factor (CCN2/CTGF) expression in human gingival fibroblasts through a RhoA-independent, Rac1/Cdc42-dependent mechanism: statins with forskolin block TGFbeta1-induced CCN2/CTGF expression.

Authors:  Samuel A Black; Philip C Trackman
Journal:  J Biol Chem       Date:  2008-02-20       Impact factor: 5.157

8.  Connective tissue growth factor and progressive fibrosis in biliary atresia.

Authors:  Hiroyuki Kobayashi; Nobukazu Hayashi; Kenji Hayashi; Atsuyuki Yamataka; Geoffrey J Lane; Takeshi Miyano
Journal:  Pediatr Surg Int       Date:  2005-01       Impact factor: 1.827

9.  Domain-and species-specific monoclonal antibodies recognize the Von Willebrand Factor-C domain of CCN5.

Authors:  Lan Wei; Frank McKeon; Joshua W Russo; Joan Lemire; John Castellot
Journal:  J Cell Commun Signal       Date:  2009-04-29       Impact factor: 5.782

10.  Connective tissue growth factor (CTGF, CCN2) gene regulation: a potent clinical bio-marker of fibroproliferative disease?

Authors:  Andrew Leask; Sunil K Parapuram; Xu Shi-Wen; D J Abraham
Journal:  J Cell Commun Signal       Date:  2009-01-21       Impact factor: 5.782
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