Structure of human G protein G gamma 5 gene GNG5.

Heterotrimeric G-proteins consist of alpha, beta and gamma subunits that together function in numerous signal transduction pathways. Ggamma subunits form dimers with Gbeta-subunits which together can significantly contribute to signal transduction. So far 11 Ggamma subunit isoforms have been found. Ggamma5 appears to be the most prominently occurring Ggamma-subunit and we now report the genomic structure of human GNG5. The gene spans 6 kb and consists of four exons that range from 92 bp to 290 bp and three introns that range from 134 bp to 3.3 kb. Intron-exon boundaries conform to GT-AG consensus splice junctions. Alternative transcriptional start sites that result from two separate, closely linked promoters in the 5'-flanking region of the gene were confirmed by luciferase reporter-gene assay. Copyright 1998 Academic Press.