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Literature DB >> 979067

Clinical correlates of in vitro effect of adriamycin on advanced lung carcinoma.

Abstract

The effect of 1.38 X 10(-5) M adriamycin on tritiated uridine incorporation was studied after 3 hours treatment of suspensions of 25 advanced human lung carcinomas in vitro. The results were correlated with the responses to clinical therapy. All tumours which showed an inhibition of uridine incorporation in vitro of more than 40% were also sensitive to clinical treatment with adriamycin.

Entities: Chemical Disease Species

Mesh：

Substances：
RNA, Neoplasm
Doxorubicin

Year: 1976 PMID： 979067 DOI： 10.1007/BF01469146

Source DB: PubMed Journal: Klin Wochenschr ISSN： 0023-2173

27 in total

1. Sensitivity tests of tumors to cytostatic agents. II. Investigation on human tumors.

Authors: J Mattern; M Kaufmann; H Hinderer; K Wayss; M Volm
Journal: Z Krebsforsch Klin Onkol Cancer Res Clin Oncol Date: 1975

2. Autoradiographic studies of in vitro incorporation of uridine and thymidine by human tumor tissue.

Authors: W H WOLBERG; R R BROWN
Journal: Cancer Res Date: 1962-10 Impact factor: 12.701

3. [Selective tumour chemotherapy using oncobiograms (author's transl)].

Authors: M Volm; M Kaufmann; K Wayss; K Goerttler; J Mattern
Journal: Dtsch Med Wochenschr Date: 1974-01-11 Impact factor: 0.628

Review 4. Monochemotherapy of bronchogenic carcinoma withs special reference to cell type.

Authors: O S Selawry
Journal: Cancer Chemother Rep 3 Date: 1973-03

5. Remission rates, survival, and prognostic factors in combination chemotherapy for bronchogenic carcinoma.

Authors: P Alberto
Journal: Cancer Chemother Rep 3 Date: 1973-03

6. The effects of cytostatic drugs on transplanted tumours. An investigation of the correlation between in vivo and in vitro results.

Authors: M Volm; J Mattern; K Wayss
Journal: Arch Geschwulstforsch Date: 1974

5. [Investigations about the incorporation of nucleotide precursors in single cell suspensions of ovarian- and cervix-carcinomas under the influence of cytostatic therapy (author's transl)].

Authors: G Teufel; A Pfleiderer; O Doerjer; J Weigand
Journal: Arch Gynakol Date: 1977-09-30

5 in total

Clinical correlates of in vitro effect of adriamycin on advanced lung carcinoma.

1. Sensitivity tests of tumors to cytostatic agents. II. Investigation on human tumors.

2. Autoradiographic studies of in vitro incorporation of uridine and thymidine by human tumor tissue.

3. [Selective tumour chemotherapy using oncobiograms (author's transl)].

Review 4. Monochemotherapy of bronchogenic carcinoma withs special reference to cell type.

5. Remission rates, survival, and prognostic factors in combination chemotherapy for bronchogenic carcinoma.

6. The effects of cytostatic drugs on transplanted tumours. An investigation of the correlation between in vivo and in vitro results.

7. [Quick method for sensitivity tests of malignant tumors against antineoplastic agents].

8. Adriamycin (NSC-123,127): a new antibiotic with antitumor activity.

9. [Rapid method for quantitative evaluation of cytotoxic activity in tissue culture by electronic cell counting].

10. [Possibilities and limits of pre-therapeutic neoplasm sensitivity cytostatics tests under short-term conditions].

1. In vitro chemosensitivity testing in the treatment of ovarian carcinoma.

2. Detection of induced tumour-resistance to cyclophosphamide by the in vitro short term test.

3. Detection of induced resistance in short-term-tests. Adriamycin-resistant sarcoma 180.

4. [In vitro and in vivo sensitivity of animal and human melanomas to various chemotherapeutical agents].

5. [Investigations about the incorporation of nucleotide precursors in single cell suspensions of ovarian- and cervix-carcinomas under the influence of cytostatic therapy (author's transl)].