Literature DB >> 9789822

Molecular mechanisms for the regulation of the expression and function of muscarinic acetylcholine receptors.

S E Hamilton1, M L Schlador, L A McKinnon, R S Chmelar, N M Nathanson.   

Abstract

The regulation of muscarinic acetylcholine receptor expression and function was investigated in cultured cells and in knockout mice. Muscarinic agonist exposure causes m2 receptor desensitization and sequestration and decreases the expression of cardiac potassium channels. The expression of m2 receptors in chick retina is regulated by a developmentally regulated secreted factor. Mice lacking the m1 receptor exhibit a loss of muscarinic regulation of M-current potassium channel activity and pilocarpine-induced seizures.

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Year:  1998        PMID： 9789822     DOI： 10.1016/s0928-4257(98)80032-6

Source DB:  PubMed          Journal:  J Physiol Paris        ISSN： 0928-4257


  7 in total

Review 1.  Functional M3 muscarinic acetylcholine receptors in mammalian hearts.

Authors:  Zhiguo Wang; Hong Shi; Huizhen Wang
Journal:  Br J Pharmacol       Date:  2004-05-17       Impact factor: 8.739

2.  Gene-based analysis suggests association of the nicotinic acetylcholine receptor beta1 subunit (CHRNB1) and M1 muscarinic acetylcholine receptor (CHRM1) with vulnerability for nicotine dependence.

Authors:  Xiang-Yang Lou; Jennie Z Ma; Thomas J Payne; Joke Beuten; Karen M Crew; Ming D Li
Journal:  Hum Genet       Date:  2006-07-28       Impact factor: 4.132

3.  IL-4 Induces Cholinergic Differentiation of Retinal Cells In Vitro.

Authors:  Marcelo Gomes Granja; Luis Eduardo Gomes Braga; Raul Carpi-Santos; Leandro de Araujo-Martins; Nilson Nunes-Tavares; Karin C Calaza; Aline Araujo Dos Santos; Elizabeth Giestal-de-Araujo
Journal:  Cell Mol Neurobiol       Date:  2015-02-15       Impact factor: 5.046

4.  Single nucleotide polymorphisms of the human M1 muscarinic acetylcholine receptor gene.

Authors:  J L Lucas; J A DeYoung; W Sadee
Journal:  AAPS PharmSci       Date:  2001

5.  The efficacy of cevimeline hydrochloride in the treatment of xerostomia in Sjögren's syndrome in southern Chinese patients: a randomised double-blind, placebo-controlled crossover study.

Authors:  K C M Leung; A S McMillan; M C M Wong; W K Leung; M Y Mok; C S Lau
Journal:  Clin Rheumatol       Date:  2007-09-26       Impact factor: 2.980

6.  Calmodulin binding to peptides derived from the i3 loop of muscarinic receptors.

Authors:  Julie L Lucas; Danxin Wang; Wolfgang Sadée
Journal:  Pharm Res       Date:  2006-04       Impact factor: 4.200

7.  A Novel Genotyping Method for Detection of the Muscarinic Receptor M1 Gene rs2067477 Polymorphism and Its Genotype/Allele Frequencies in a Turkish Population.

Authors:  Fezile Özdemir; Yağmur Kır; Kenan Can Tok; Bora Baskak; Halit Sinan Süzen
Journal:  Turk J Pharm Sci       Date:  2020-12-23
  7 in total

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