Literature DB >> 9789812

The role of neuronal nicotinic acetylcholine receptors in antinociception: effects of ABT-594.

M W Decker1, P Curzon, M W Holladay, A L Nikkel, R S Bitner, A W Bannon, D L Donnelly-Roberts, P S Puttfarcken, T A Kuntzweiler, C A Briggs, M Williams, S P Arneric.   

Abstract

ABT-594, a nicotinic acetylcholine receptor agonist, has antinociceptive effects in rat models of acute thermal, persistent chemical, and neuropathic pain. Direct injection of ABT-594 into the nucleus raphe magnus (NRM) is antinociceptive in a thermal threshold test and destruction of serotonergic neurons in the NRM attenuates the effect of systemic ABT-594. However, lidocaine-inactivation of the NRM prevents the antinociceptive effect of systemic (-)-nicotine but not that of systemic ABT-594.

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Year:  1998        PMID： 9789812     DOI： 10.1016/s0928-4257(98)80014-4

Source DB:  PubMed          Journal:  J Physiol Paris        ISSN： 0928-4257


  6 in total

1.  Identification of novel α4β2-nicotinic acetylcholine receptor (nAChR) agonists based on an isoxazole ether scaffold that demonstrate antidepressant-like activity.

Authors:  Li-Fang Yu; Werner Tückmantel; J Brek Eaton; Barbara Caldarone; Allison Fedolak; Taleen Hanania; Dani Brunner; Ronald J Lukas; Alan P Kozikowski
Journal:  J Med Chem       Date:  2012-01-04       Impact factor: 7.446

Review 2.  Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system.

Authors:  Antoine Taly; Pierre-Jean Corringer; Denis Guedin; Pierre Lestage; Jean-Pierre Changeux
Journal:  Nat Rev Drug Discov       Date:  2009-09       Impact factor: 84.694

Review 3.  Nicotinic acetylcholine receptor ligands, a patent review (2006-2011).

Authors:  Daniela Gündisch; Christoph Eibl
Journal:  Expert Opin Ther Pat       Date:  2011-12       Impact factor: 6.674

4.  Nicotinic acetylcholine receptors expressed in the ventralposterolateral thalamic nucleus play an important role in anti-allodynic effects.

Authors:  M Ueda; Y Iida; A Tominaga; T Yoneyama; M Ogawa; Y Magata; H Nishimura; Y Kuge; H Saji
Journal:  Br J Pharmacol       Date:  2010-02-05       Impact factor: 8.739

5.  Rostral ventral medulla cholinergic mechanism in pain-induced analgesia.

Authors:  Robert W Gear; Jon D Levine
Journal:  Neurosci Lett       Date:  2009-08-20       Impact factor: 3.046

6.  Plasticity in Brainstem Mechanisms of Pain Modulation by Nicotinic Acetylcholine Receptors in the Rat.

Authors:  Francis J Jareczek; Stephanie R White; Donna L Hammond
Journal:  eNeuro       Date:  2017-02-01
  6 in total

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