OBJECTIVES: Several observations reported earlier indicated that the selectins, in particular E-selectin, might be involved in angiogenesis; however, mice deficient in the endothelial selectins develop normally. To clarify the role of endothelial selectins in angiogenesis, we have studied experimentally induced angiogenesis in selectin-deficient mice. METHODS: Hydron pellets containing either basic fibroblast growth factor or the inflammatory cytokine tumor necrosis factor alpha were implanted into the corneas of wild-type and P- and/or E-selectin-deficient mice. RESULTS: The lengths and circumferential range of the newly formed blood vessels in the corneas of the endothelial selectin-deficient mice were similar to those of wild-type mice. CONCLUSION: The endothelial selectins are not essential in experimentally induced angiogenesis in vivo.
OBJECTIVES: Several observations reported earlier indicated that the selectins, in particular E-selectin, might be involved in angiogenesis; however, mice deficient in the endothelial selectins develop normally. To clarify the role of endothelial selectins in angiogenesis, we have studied experimentally induced angiogenesis in selectin-deficient mice. METHODS: Hydron pellets containing either basic fibroblast growth factor or the inflammatory cytokine tumor necrosis factor alpha were implanted into the corneas of wild-type and P- and/or E-selectin-deficient mice. RESULTS: The lengths and circumferential range of the newly formed blood vessels in the corneas of the endothelial selectin-deficient mice were similar to those of wild-type mice. CONCLUSION: The endothelial selectins are not essential in experimentally induced angiogenesis in vivo.
Authors: Carolyn A Staton; Stephen M Stribbling; Simon Tazzyman; Russell Hughes; Nicola J Brown; Claire E Lewis Journal: Int J Exp Pathol Date: 2004-10 Impact factor: 1.925
Authors: Janka Kisucka; Catherine E Butterfield; Dan G Duda; Sarah C Eichenberger; Simin Saffaripour; Jerry Ware; Zaverio M Ruggeri; Rakesh K Jain; Judah Folkman; Denisa D Wagner Journal: Proc Natl Acad Sci U S A Date: 2006-01-17 Impact factor: 11.205
Authors: Eva Zetterberg; Maria Verrucci; Fabrizio Martelli; Maria Zingariello; Laura Sancillo; Emanuela D'Amore; Rosa Alba Rana; Anna Rita Migliaccio Journal: Platelets Date: 2013-10-31 Impact factor: 3.862
Authors: Chad L Carr; Yue Qi; Brian Davidson; Scott Chadderdon; Ananda R Jayaweera; J Todd Belcik; Cameron Benner; Aris Xie; Jonathan R Lindner Journal: Arterioscler Thromb Vasc Biol Date: 2011-11 Impact factor: 8.311
Authors: Ying Yu; Karen S Moulton; Mohamed K Khan; Sabrina Vineberg; Eileen Boye; Vannessa M Davis; Peter E O'Donnell; Joyce Bischoff; David S Milstone Journal: Proc Natl Acad Sci U S A Date: 2004-05-17 Impact factor: 11.205