Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Conservation of gene order: a fingerprint of proteins that physically interact.

Literature DB >> 9787636

Conservation of gene order: a fingerprint of proteins that physically interact.

Abstract

A systematic comparison of nine bacterial and archaeal genomes reveals a low level of gene-order (and operon architecture) conservation. Nevertheless, a number of gene pairs are conserved. The proteins encoded by conserved gene pairs appear to interact physically. This observation can therefore be used to predict functions of, and interactions between, prokaryotic gene products.

Mesh：

Substances：

Year: 1998 PMID： 9787636 DOI： 10.1016/s0968-0004(98)01274-2

Source DB: PubMed Journal: Trends Biochem Sci ISSN： 0968-0004 Impact factor: 13.807

Keyword Cloud
Cited

342 in total

Review 1. P(II) signal transduction proteins, pivotal players in microbial nitrogen control.

Authors: T Arcondéguy; R Jack; M Merrick
Journal: Microbiol Mol Biol Rev Date: 2001-03 Impact factor: 11.056

2. Predicting regulons and their cis-regulatory motifs by comparative genomics.

Authors: A Manson McGuire; G M Church
Journal: Nucleic Acids Res Date: 2000-11-15 Impact factor: 16.971

3. Automatic detection of conserved gene clusters in multiple genomes by graph comparison and P-quasi grouping.

Authors: W Fujibuchi; H Ogata; H Matsuda; M Kanehisa
Journal: Nucleic Acids Res Date: 2000-10-15 Impact factor: 16.971

4. The mitochondrial genome of the stramenopile alga Chrysodidymus synuroideus. Complete sequence, gene content and genome organization.

Authors: J M Chesnick; M Goff; J Graham; C Ocampo; B F Lang; E Seif; G Burger
Journal: Nucleic Acids Res Date: 2000-07-01 Impact factor: 16.971

5. Genes linked by fusion events are generally of the same functional category: a systematic analysis of 30 microbial genomes.

Authors: I Yanai; A Derti; C DeLisi
Journal: Proc Natl Acad Sci U S A Date: 2001-07-03 Impact factor: 11.205

Conservation of gene order: a fingerprint of proteins that physically interact.

Review 1. P(II) signal transduction proteins, pivotal players in microbial nitrogen control.

2. Predicting regulons and their cis-regulatory motifs by comparative genomics.

3. Automatic detection of conserved gene clusters in multiple genomes by graph comparison and P-quasi grouping.

4. The mitochondrial genome of the stramenopile alga Chrysodidymus synuroideus. Complete sequence, gene content and genome organization.

5. Genes linked by fusion events are generally of the same functional category: a systematic analysis of 30 microbial genomes.

6. Predictome: a database of putative functional links between proteins.

7. The identification of functional modules from the genomic association of genes.

8. Interaction generality, a measurement to assess the reliability of a protein-protein interaction.

9. Membrane sequestration of the signal transduction protein GlnK by the ammonium transporter AmtB.

10. Connected gene neighborhoods in prokaryotic genomes.