Literature DB >> 978682

Metabolic N-demethylation of nicotine. Trapping of a reactive iminium species with cyanide ion.

T L Nguyen, L D Gruenke, N Castagnoli.   

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Year:  1976        PMID： 978682     DOI： 10.1021/jm00231a018

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  5 in total

1.  Catalytic mechanism of cytochrome P450 for 5'-hydroxylation of nicotine: fundamental reaction pathways and stereoselectivity.

Authors:  Dongmei Li; Xiaoqin Huang; Keli Han; Chang-Guo Zhan
Journal:  J Am Chem Soc       Date:  2011-04-22       Impact factor: 15.419

2.  In vitro microsomal [correction of mircosomal] metabolism of N-benzyl and N-benzoylnornicotine derivates by rat.

Authors:  F Yilmaz; F Aricioglu Kartal; M Ulgen; John W Gorrod
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2004 Oct-Dec       Impact factor: 2.441

3.  Fundamental reaction pathways for cytochrome P450-catalyzed 5'-hydroxylation and N-demethylation of nicotine.

Authors:  Dongmei Li; Yong Wang; Keli Han; Chang-Guo Zhan
Journal:  J Phys Chem B       Date:  2010-07-15       Impact factor: 2.991

4.  Catalytic mechanism of cytochrome P450 for N-methylhydroxylation of nicotine: reaction pathways and regioselectivity of the enzymatic nicotine oxidation.

Authors:  Dongmei Li; Xiaoqin Huang; Jianping Lin; Chang-Guo Zhan
Journal:  Dalton Trans       Date:  2013-01-09       Impact factor: 4.390

Review 5.  The metabolism of alicyclic amines to reactive iminium ion intermediates.

Authors:  J W Gorrod; G Aislaitner
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1994 Jul-Sep       Impact factor: 2.441
  5 in total

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