INTRODUCTION: The regulatory role of apolipoprotein E in lipid transport and metabolism was utilized to investigate the allelic association between the apolipoprotein E4 (apoE4) allele and vascular dementia (VD) in a selected sample of Hungarian patients with multiple deep subcortical infarcts and leukoaraiosis. MATERIAL AND METHODS: Thirty-four Caucasian VD cases and 79 healthy control probands were involved in this study according to the criteria of ICD-10 and NINDS-AIREN International Workshop Diagnostic Criteria. The genomic DNA was isolated from whole blood and the apoE alleles were determined by polymerase chain reaction. RESULTS: The E2, E3 and E4 allele frequencies in the VD group were 5%, 76%, and 19%, respectively; and significant (P<0.03) differences were found in comparison with the data on the healthy controls (E2, 6%; E3, 87%; E4, 8%). The apoE4 allele frequency was intermediate between HC and Alzheimer's dementia group (28%). CONCLUSION: These results indicate that the apoE4 allele could be a risk factor not only for certain primary degenerative, but also for vascular dementias.
INTRODUCTION: The regulatory role of apolipoprotein E in lipid transport and metabolism was utilized to investigate the allelic association between the apolipoprotein E4 (apoE4) allele and vascular dementia (VD) in a selected sample of Hungarian patients with multiple deep subcortical infarcts and leukoaraiosis. MATERIAL AND METHODS: Thirty-four Caucasian VD cases and 79 healthy control probands were involved in this study according to the criteria of ICD-10 and NINDS-AIREN International Workshop Diagnostic Criteria. The genomic DNA was isolated from whole blood and the apoE alleles were determined by polymerase chain reaction. RESULTS: The E2, E3 and E4 allele frequencies in the VD group were 5%, 76%, and 19%, respectively; and significant (P<0.03) differences were found in comparison with the data on the healthy controls (E2, 6%; E3, 87%; E4, 8%). The apoE4 allele frequency was intermediate between HC and Alzheimer's dementia group (28%). CONCLUSION: These results indicate that the apoE4 allele could be a risk factor not only for certain primary degenerative, but also for vascular dementias.
Authors: Anna Juhász; András Palotás; Zoltán Janka; Agnes Rimanóczy; Miklós Palotás; Nikoletta Bódi; Krisztina Boda; Marianna Zana; Gábor Vincze; János Kálmán Journal: Neurochem Res Date: 2005-05 Impact factor: 3.996
Authors: Yi-Fang Chuang; Kathleen M Hayden; Maria C Norton; Joann Tschanz; John C S Breitner; Kathleen A Welsh-Bohmer; Peter P Zandi Journal: Dement Geriatr Cogn Disord Date: 2010-04-06 Impact factor: 2.959
Authors: H K Wang; H C Fung; W C Hsu; Y R Wu; J C Lin; L S Ro; K H Chang; F J Hwu; Y Hsu; S Y Huang; G J Lee-Chen; C M Chen Journal: J Neural Transm (Vienna) Date: 2006-02-09 Impact factor: 3.575