Halawanones A-D, new polycyclic quinones from a marine-derived streptomycete

Four new quinone-containing metabolites, halawanones A-D (1-4), have been isolated along with the known compound nanaomycin D (5) from liquid cultures of a streptomycete obtained from a sediment sample collected in the estuarine environment at the mouth of Halawa stream, Oahu. The structures of the new compounds were determined through the interpretation of spectral data. The absolute stereochemistries were determined using a combination of CD and NMR.