Literature DB >> 9782452

Functional determinants by which snake and cone snail toxins block the alpha 7 neuronal nicotinic acetylcholine receptors.

D Servent1, H L Thanh, S Antil, D Bertrand, P J Corringer, J P Changeux, A Ménez.   

Abstract

Snakes and cone snails produce toxins which block muscular and/or neuronal nicotinic acetylcholine receptors (AChRs). This paper mostly focuses on the determinants by which a snake long chain curaremimetic toxin and the cone snail toxin ImI bind specifically to the alpha 7 neuronal receptor. In both cases, the site involves a small turn-like structure constrained by two half-cystines.

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Year:  1998        PMID: 9782452     DOI: 10.1016/s0928-4257(98)80146-0

Source DB:  PubMed          Journal:  J Physiol Paris        ISSN: 0928-4257


  8 in total

1.  A comparative study on selectivity of alpha-conotoxins GI and ImI using their synthetic analogues and derivatives.

Authors:  Igor E Kasheverov; Maxim N Zhmak; Innokenty V Maslennikov; Yuri N Utkin; Victor I Tsetlin
Journal:  Neurochem Res       Date:  2003-04       Impact factor: 3.996

2.  Structural determinants of selective alpha-conotoxin binding to a nicotinic acetylcholine receptor homolog AChBP.

Authors:  Chris Ulens; Ronald C Hogg; Patrick H Celie; Daniel Bertrand; Victor Tsetlin; August B Smit; Titia K Sixma
Journal:  Proc Natl Acad Sci U S A       Date:  2006-02-27       Impact factor: 11.205

3.  Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations.

Authors:  Scott B Hansen; Gerlind Sulzenbacher; Tom Huxford; Pascale Marchot; Palmer Taylor; Yves Bourne
Journal:  EMBO J       Date:  2005-09-29       Impact factor: 11.598

4.  Blockade of neuronal α7-nAChR by α-conotoxin ImI explained by computational scanning and energy calculations.

Authors:  Rilei Yu; David J Craik; Quentin Kaas
Journal:  PLoS Comput Biol       Date:  2011-03-03       Impact factor: 4.475

Review 5.  Synthetic α-conotoxin mutants as probes for studying nicotinic acetylcholine receptors and in the development of novel drug leads.

Authors:  Christopher J Armishaw
Journal:  Toxins (Basel)       Date:  2010-06-14       Impact factor: 4.546

6.  Less is More: Design of a Highly Stable Disulfide-Deleted Mutant of Analgesic Cyclic α-Conotoxin Vc1.1.

Authors:  Rilei Yu; Victoria A L Seymour; Géza Berecki; Xinying Jia; Muharrem Akcan; David J Adams; Quentin Kaas; David J Craik
Journal:  Sci Rep       Date:  2015-08-20       Impact factor: 4.379

7.  Structure of alpha-conotoxin BuIA: influences of disulfide connectivity on structural dynamics.

Authors:  Ai-Hua Jin; Hemma Brandstaetter; Simon T Nevin; Chia Chia Tan; Richard J Clark; David J Adams; Paul F Alewood; David J Craik; Norelle L Daly
Journal:  BMC Struct Biol       Date:  2007-04-20

8.  Interactions of Globular and Ribbon [γ4E]GID with α4β2 Neuronal Nicotinic Acetylcholine Receptor.

Authors:  Xiaosa Wu; David J Craik; Quentin Kaas
Journal:  Mar Drugs       Date:  2021-08-26       Impact factor: 5.118

  8 in total

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