European serotype PRRSV vaccine protects against European serotype challenge whereas an American serotype vaccine does not.

Pigs were either vaccinated with an American serotype Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) vaccine or with a European serotype vaccine. A control group of was left unvaccinated. At four weeks after vaccination the PRRSV-specific antibody titres were determined and one third of each group was challenged with a Spanish, one third with a German and one third with a Dutch PRRSV wild type strain. The serological responses, measured at 4 weeks after vaccination, confirmed that both vaccines were of a different serotype. It was demonstrated that vaccination with an American serotype vaccine slightly reduced the amount of viraemia after challenge with European PRRSV wild type strains. Only after challenge with the Spanish PRRSV strain a moderate, and statistically significant, reduction in viraemia was observed. This is in contrast to vaccination with a European vaccine strain, where viraemia was completely suppressed after challenge with the German PRRSV isolate and almost completely suppressed after challenge with the Spanish and Dutch isolates.