| Literature DB >> 9782093 |
K J Holroyd1, L C Martinati, E Trabetti, T Scherpbier, S M Eleff, A L Boner, P F Pignatti, M B Kiser, C R Dragwa, F Hubbard, C D Sullivan, L Grasso, C J Messler, M Huang, Y Hu, N C Nicolaides, K H Buetow, R C Levitt.
Abstract
We examined the long arm XY pseudoautosomal region for linkage to asthma, serum IgE, and bronchial hyperresponsiveness. In 57 Caucasian families multipoint nonparametric analyses provide evidence for linkage between DXYS154 and bronchial hyperresponsiveness (P = 0.000057) or asthma (P = 0.00065). This genomic region is approximately 320 kb in size and contains the interleukin-9 receptor gene. These results suggest that a gene controlling asthma and bronchial hyperresponsiveness maybe located in this region and that the interleukin-9 receptor is a potential candidate. Copyright 1998 Academic Press.Entities:
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Year: 1998 PMID： 9782093 DOI： 10.1006/geno.1998.5445
Source DB: PubMed Journal: Genomics ISSN： 0888-7543 Impact factor: 5.736