| Literature DB >> 9781781 |
M Piepoli1, G Q Villani, P Ponikowski, A Wright, M D Flather, A J Coats.
Abstract
Unlike other antiarrhythmic class I drugs, amiodarone showed in preliminary studies, benefits also in patients with left ventricular dysfunction. These positive results have induced the development of large randomised controlled studies: their results are reviewed and the controversial points are discussed. In a meta-analysis of randomised controlled trials the use of amiodarone in heart failure was associated with an approximate 20 to 25% reduction in deaths. However, amiodarone was also associated with a 120 to 124% increase in side effects.Entities:
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Year: 1998 PMID： 9781781 DOI： 10.1016/s0167-5273(98)00184-3
Source DB: PubMed Journal: Int J Cardiol ISSN： 0167-5273 Impact factor: 4.164