Literature DB >> 9781679

Characterization of a novel structural member, LukE-LukD, of the bi-component staphylococcal leucotoxins family.

A Gravet1, D A Colin, D Keller, R Girardot, H Monteil, G Prévost, R Giradot.   

Abstract

A new member of the staphylococcal bi-component leucotoxins family, LukE (32 kDa) and LukD (34.3 kDa) has been characterized from Staphylococcus aureus strain Newman. LukE was 58-68% identical with the class S proteins, whereas LukD was 71-77% identical with the class F proteins of the family. A partial immunoreactivity with the various affinity-purified antibodies specific for the other proteins was observed. Immunoprecipitation assay and gene probing confirmed a 30% frequency among human clinical isolates, differing from the distribution of the other known leucotoxins (P<0.005). LukE+LukD was as effective as the Panton-Valentine leucocidin for inducing dermonecrosis when injected in the rabbit skin, but not hemolytic and poorly leucotoxic compared to other leucotoxins expressed by Staphylococcus aureus.

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Year:  1998        PMID： 9781679     DOI： 10.1016/s0014-5793(98)01130-2

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  72 in total

1.  Subunit composition of a bicomponent toxin: staphylococcal leukocidin forms an octameric transmembrane pore.

Authors:  George Miles; Liviu Movileanu; Hagan Bayley
Journal:  Protein Sci       Date:  2002-04       Impact factor: 6.725

2.  Retrieving biological activity from LukF-PV mutants combined with different S components implies compatibility between the stem domains of these staphylococcal bicomponent leucotoxins.

Authors:  S Werner; D A Colin; M Coraiola; G Menestrina; H Monteil; G Prévost
Journal:  Infect Immun       Date:  2002-03       Impact factor: 3.441

3.  Staphylococcus aureus leucocidin ED contributes to systemic infection by targeting neutrophils and promoting bacterial growth in vivo.

Authors:  Francis Alonzo; Meredith A Benson; John Chen; Richard P Novick; Bo Shopsin; Victor J Torres
Journal:  Mol Microbiol       Date:  2011-12-20       Impact factor: 3.501

4.  Heavy chain-only antibodies and tetravalent bispecific antibody neutralizing Staphylococcus aureus leukotoxins.

Authors:  Benoît-Joseph Laventie; Hendrik Jan Rademaker; Maher Saleh; Ernie de Boer; Rick Janssens; Tristan Bourcier; Audrey Subilia; Luc Marcellin; Rien van Haperen; Joyce H G Lebbink; Tao Chen; Gilles Prévost; Frank Grosveld; Dubravka Drabek
Journal:  Proc Natl Acad Sci U S A       Date:  2011-09-19       Impact factor: 11.205

5.  Crystallization and preliminary crystallographic studies of both components of the staphylococcal LukE-LukD leukotoxin.

Authors:  Romain Galy; Fabien Bergeret; Daniel Keller; Lionel Mourey; Gilles Prévost; Laurent Maveyraud
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2012-05-23

6.  Homologous versus heterologous interactions in the bicomponent staphylococcal gamma-haemolysin pore.

Authors:  Gabriella Viero; Romina Cunaccia; Gilles Prévost; Sandra Werner; Henri Monteil; Daniel Keller; Olivier Joubert; Gianfranco Menestrina; Mauro Dalla Serra
Journal:  Biochem J       Date:  2006-02-15       Impact factor: 3.857

Review 7.  The potential use of toxin antibodies as a strategy for controlling acute Staphylococcus aureus infections.

Authors:  Gordon Y C Cheung; Michael Otto
Journal:  Expert Opin Ther Targets       Date:  2012-04-25       Impact factor: 6.902

Review 8.  Role of pore-forming toxins in bacterial infectious diseases.

Authors:  Ferdinand C O Los; Tara M Randis; Raffi V Aroian; Adam J Ratner
Journal:  Microbiol Mol Biol Rev       Date:  2013-06       Impact factor: 11.056

9.  Analysis of the specificity of Panton-Valentine leucocidin and gamma-hemolysin F component binding.

Authors:  Florent Meyer; Raymonde Girardot; Yves Piémont; Gilles Prévost; Didier A Colin
Journal:  Infect Immun       Date:  2008-10-06       Impact factor: 3.441

10.  Sensitive and specific detection of staphylococcal epidermolysins A and B in broth cultures by flow cytometry-assisted multiplex immunoassay.

Authors:  Olivier Joubert; Daniel Keller; Anne Pinck; Henri Monteil; Gilles Prévost
Journal:  J Clin Microbiol       Date:  2005-03       Impact factor: 5.948
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