Literature DB >> 977921

Gerontological data of C57BL/6J mice. II. Changes in blood cell counts in the course of natural aging.

H G Leuenberger, I Kunstýr.   

Abstract

A group of 1,052 C578L/6J mice -- 296 males and 756 females - was kept under well defined, clean, conventional conditions from the age of 6 weeks until natural death. At regular time intervals several hematological values were examined from 50 to 60 randomly selected animals of each sex and statistically evaluated. The hematological investigations did not reveal any important sex-related differences. A significant gradual decrease of the RBC counts and hemoglobin content was observed during the life-span. Lymphocyte and total WBC counts were subject to considerable variation. They decreased in the first two-thirds of life and increased in the last third. Neutrophils remained rather stable and exhibited an increasing trend in the higher age. The relative level of lymphocytes decreased signficantly in favour of neutrophils during natural aging.

Entities:  

Mesh：

Year:  1976        PMID： 977921     DOI： 10.1093/geronj/31.6.648

Source DB:  PubMed          Journal:  J Gerontol        ISSN： 0022-1422


  10 in total

1.  Age-dependent relaxation of gene repression: increase of endogenous murine leukemia virus-related and globin-related RNA in brain and liver of mice.

Authors:  T Ono; R G Cutler
Journal:  Proc Natl Acad Sci U S A       Date:  1978-09       Impact factor: 11.205

2.  Peromyscus leucopus mice: a potential animal model for haematological studies.

Authors:  Yu Sun; Marie J Desierto; Yasutaka Ueda; Sachiko Kajigaya; Jichun Chen; Neal S Young
Journal:  Int J Exp Pathol       Date:  2014-08-12       Impact factor: 1.925

3.  High stability of blood parameters during mouse lifespan: sex-specific effects of every-other-day fasting.

Authors:  Maria M Bayliak; Oksana M Sorochynska; Oksana V Kuzniak; Ivanna Z Drohomyretska; Andriy Ya Klonovskyi; Anastasia O Hrushchenko; Myroslava V Vatashchuk; Nadia M Mosiichuk; Kenneth B Storey; Olga Garaschuk; Volodymyr I Lushchak
Journal:  Biogerontology       Date:  2022-08-01       Impact factor: 4.284

4.  New intranasal and injectable gene therapy for healthy life extension.

Authors:  Dabbu Kumar Jaijyan; Anca Selariu; Ruth Cruz-Cosme; Mingming Tong; Shaomin Yang; Alketa Stefa; David Kekich; Junichi Sadoshima; Utz Herbig; Qiyi Tang; George Church; Elizabeth L Parrish; Hua Zhu
Journal:  Proc Natl Acad Sci U S A       Date:  2022-05-10       Impact factor: 12.779

5.  Rapamycin extends murine lifespan but has limited effects on aging.

Authors:  Frauke Neff; Diana Flores-Dominguez; Devon P Ryan; Marion Horsch; Susanne Schröder; Thure Adler; Luciana Caminha Afonso; Juan Antonio Aguilar-Pimentel; Lore Becker; Lillian Garrett; Wolfgang Hans; Moritz M Hettich; Richard Holtmeier; Sabine M Hölter; Kristin Moreth; Cornelia Prehn; Oliver Puk; Ildikó Rácz; Birgit Rathkolb; Jan Rozman; Beatrix Naton; Rainer Ordemann; Jerzy Adamski; Johannes Beckers; Raffi Bekeredjian; Dirk H Busch; Gerhard Ehninger; Jochen Graw; Heinz Höfler; Martin Klingenspor; Thomas Klopstock; Markus Ollert; Jörg Stypmann; Eckhard Wolf; Wolfgang Wurst; Andreas Zimmer; Helmut Fuchs; Valérie Gailus-Durner; Martin Hrabe de Angelis; Dan Ehninger
Journal:  J Clin Invest       Date:  2013-07-25       Impact factor: 14.808

6.  Long-term every-other-day administration of DMAMCL has little effect on aging and age-associated physiological decline in mice.

Authors:  Zhaomeng Sun; Lijun Zhao; Li Su; Qing Fang; Chenzhong Xu; Yuanyuan Su; Yao Liang; Guodong Li; Yanxue Xue; Tanjun Tong; Jun Chen
Journal:  Aging (Albany NY)       Date:  2019-05-02       Impact factor: 5.682

7.  Sex-Specific Differences of Adenosine Triphosphate Levels in Red Blood Cells Isolated From ApoE/LDLR Double-Deficient Mice.

Authors:  Fatih Celal Alcicek; Tasnim Mohaissen; Katarzyna Bulat; Jakub Dybas; Ewa Szczesny-Malysiak; Magdalena Kaczmarska; Magdalena Franczyk-Zarow; Renata Kostogrys; Katarzyna M Marzec
Journal:  Front Physiol       Date:  2022-02-18       Impact factor: 4.566

Review 8.  Longevity, aging and rapamycin.

Authors:  Dan Ehninger; Frauke Neff; Kan Xie
Journal:  Cell Mol Life Sci       Date:  2014-11       Impact factor: 9.261

9.  Ndfip2 is a potential regulator of the iron transporter DMT1 in the liver.

Authors:  Natalie J Foot; Kelly M Gembus; Kimberly Mackenzie; Sharad Kumar
Journal:  Sci Rep       Date:  2016-04-06       Impact factor: 4.379

10.  Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice.

Authors:  Kan Xie; Frauke Neff; Astrid Markert; Jan Rozman; Juan Antonio Aguilar-Pimentel; Oana Veronica Amarie; Lore Becker; Robert Brommage; Lillian Garrett; Kristin S Henzel; Sabine M Hölter; Dirk Janik; Isabelle Lehmann; Kristin Moreth; Brandon L Pearson; Ildiko Racz; Birgit Rathkolb; Devon P Ryan; Susanne Schröder; Irina Treise; Raffi Bekeredjian; Dirk H Busch; Jochen Graw; Gerhard Ehninger; Martin Klingenspor; Thomas Klopstock; Markus Ollert; Michael Sandholzer; Carsten Schmidt-Weber; Marco Weiergräber; Eckhard Wolf; Wolfgang Wurst; Andreas Zimmer; Valerie Gailus-Durner; Helmut Fuchs; Martin Hrabě de Angelis; Dan Ehninger
Journal:  Nat Commun       Date:  2017-07-24       Impact factor: 14.919
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.