Literature DB >> 9778787

Complete inhibition of SIVmac replication by its capsid mutants.

R Shimano1, R Inubushi, K Amano, T Ogasawara, H Akari, A H Koyama, M Kawamura, A Adachi.   

Abstract

Mutations were introduced into a genomic region encoding the C-terminal portion of Gag capsid protein of pathogenic simian immunodeficiency virus (SIVmac239). All the mutants generated were defective for virion production and were non-infectious for monkey cells. They all efficiently suppressed the replication of wild type SIVmac in monkey cells. These results were in good agreement with those obtained for human immunodeficiency virus type 1, showing the importance of SIV/monkey model system for studies on Gag.

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Year:  1998        PMID： 9778787     DOI： 10.1023/a:1008001000878

Source DB:  PubMed          Journal:  Virus Genes        ISSN： 0920-8569            Impact factor:   2.332


  15 in total

1.  Generation of a chimeric human and simian immunodeficiency virus infectious to monkey peripheral blood mononuclear cells.

Authors:  R Shibata; M Kawamura; H Sakai; M Hayami; A Ishimoto; A Adachi
Journal:  J Virol       Date:  1991-07       Impact factor: 5.103

Review 2.  HIV with multiple gene deletions as a live attenuated vaccine for AIDS.

Authors:  R C Desrosiers
Journal:  AIDS Res Hum Retroviruses       Date:  1992-03       Impact factor: 2.205

Review 3.  Genetic variation of simian immunodeficiency viruses in nonhuman primates.

Authors:  P R Johnson; V M Hirsch
Journal:  AIDS Res Hum Retroviruses       Date:  1992-03       Impact factor: 2.205

4.  HIV-1 capsid mutants inhibit the replication of wild-type virus at both early and late infection phases.

Authors:  R A Furuta; R Shimano; T Ogasawara; R Inubushi; K Amano; H Akari; M Hatanaka; M Kawamura; A Adachi
Journal:  FEBS Lett       Date:  1997-09-29       Impact factor: 4.124

5.  Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone.

Authors:  A Adachi; H E Gendelman; S Koenig; T Folks; R Willey; A Rabson; M A Martin
Journal:  J Virol       Date:  1986-08       Impact factor: 5.103

6.  HIV-1 origins. A finger on the missing link.

Authors:  R C Desrosiers
Journal:  Nature       Date:  1990-05-24       Impact factor: 49.962

7.  Mutational analysis of HIV-1 Tat minimal domain peptides: identification of trans-dominant mutants that suppress HIV-LTR-driven gene expression.

Authors:  M Green; M Ishino; P M Loewenstein
Journal:  Cell       Date:  1989-07-14       Impact factor: 41.582

8.  Functional domain mapping of HIV-1 Gag proteins.

Authors:  M Kawamura; R Shimano; R Inubushi; K Amano; T Ogasawara; H Akari; A Adachi
Journal:  Biochem Biophys Res Commun       Date:  1997-12-18       Impact factor: 3.575

9.  Early replication block of human immunodeficiency virus type 1 in monkey cells.

Authors:  R Shibata; H Sakai; M Kawamura; K Tokunaga; A Adachi
Journal:  J Gen Virol       Date:  1995-11       Impact factor: 3.891

10.  Use of a human immunodeficiency virus type 1 Rev mutant without nucleolar dysfunction as a candidate for potential AIDS therapy.

Authors:  R A Furuta; S Kubota; M Maki; Y Miyazaki; T Hattori; M Hatanaka
Journal:  J Virol       Date:  1995-03       Impact factor: 5.103
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  1 in total

1.  Inhibition of HIV/SIV replication by dominant negative Gag mutants.

Authors:  R Shimano; R Inubushi; Y Oshima; A Adachi
Journal:  Virus Genes       Date:  1999       Impact factor: 2.198
  1 in total

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