| Literature DB >> 977773 |
A C Parker, A D Bain, W G Brydon, R A Harkness, A F Smith, I I Smith, D H Boyd.
Abstract
A patient with sea-blue histiocytosis in spleen and bone marrow with an accompanying hyperlipidaemia is described. The hyperlipidaemia was due to an increase in "free" cholesterol, lecithin, and triglycerides. Despite these findings lecithin-cholesterol acyl transferase activity was normal. Although the precise biochemical defect was not identified, there was a failure of transport of cholesterol from chylomicrons in vitro. We propose that the sea-blue histiocyte is a marker, in some cases, of abnormal lipid metabolism.Entities:
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Year: 1976 PMID： 977773 PMCID： PMC476131 DOI： 10.1136/jcp.29.7.634
Source DB: PubMed Journal: J Clin Pathol ISSN： 0021-9746 Impact factor: 3.411