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Literature DB >> 977765

Changing blood picture in sickle-cell anaemia from shortly after birth to adolescence.

Abstract

The blood picture of children with sickle-cell anaemia was found to change with age. The changes were most marked in the first year but the mean level of haemoglobin, haemoglobin F, and target cells fell until adolescence, and irreversibly sickled cells rose. Reticulocytes, Howell Jolly bodies, and normablasts altered little after one year. The fall in haemoglobin F suggested a delayed changeover from fetal to adult haemoglobin production. It was concluded that the blood changes in sickle-cell anaemia were progressive throughout childhood.

Entities: Disease Species

Mesh：

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Year: 1976 PMID： 977765 PMCID： PMC476210 DOI： 10.1136/jcp.29.10.898

Source DB: PubMed Journal: J Clin Pathol ISSN： 0021-9746 Impact factor: 3.411

6 in total

1. In vivo study of the sickle cell phenomenon.

Authors: W N JENSEN; D L RUCKNAGEL; W J TAYLOR
Journal: J Lab Clin Med Date: 1960-12

2. Amelioration of sickle cell disease by persistent fetal hemoglobin.

Authors: J F JACKSON; J L ODOM; W N BELL
Journal: JAMA Date: 1961-09-23 Impact factor: 56.272

3. Studies on abnormal hemoglobins. I. Their demonstration in sickle cell anemia and other hematologic disorders by means of alkali denaturation.

Authors: K SINGER; A I CHERNOFF; L SINGER
Journal: Blood Date: 1951-05 Impact factor: 22.113

4. Irreversibly sickled cells and splenomegaly in sickle-cell anaemia.

Authors: G R Serjeant
Journal: Br J Haematol Date: 1970-11 Impact factor: 6.998

5. Functional asplenia in sickle-cell anemia.

Authors: H A Pearson; R P Spencer; E A Cornelius
Journal: N Engl J Med Date: 1969-10-23 Impact factor: 91.245

6. Target cells in haemoglobinopathies.

Authors: L R Davis
Journal: J Clin Pathol Date: 1972-02 Impact factor: 3.411

6 in total

8 in total

Changing blood picture in sickle-cell anaemia from shortly after birth to adolescence.

1. In vivo study of the sickle cell phenomenon.

2. Amelioration of sickle cell disease by persistent fetal hemoglobin.

3. Studies on abnormal hemoglobins. I. Their demonstration in sickle cell anemia and other hematologic disorders by means of alkali denaturation.

4. Irreversibly sickled cells and splenomegaly in sickle-cell anaemia.

5. Functional asplenia in sickle-cell anemia.

6. Target cells in haemoglobinopathies.

1. Heterogeneity of sickle-cell anemia based on a profile of hematological variables.

2. Sickle-cell anaemia in infancy.

3. T1 and T2 values of human neonatal blood at 3 Tesla: Dependence on hematocrit, oxygenation, and temperature.

4. Fetal hemoglobin during infancy and in sickle cell adults.

5. Mathematical Modeling of Hydroxyurea Therapy in Individuals with Sickle Cell Disease.

6. Sickle cell disease in Saudi Arabs in early childhood.

7. Sickle cell haemoglobinopathies in England.

8. From infancy to adolescence: fifteen years of continuous treatment with hydroxyurea in sickle cell anemia.