UNLABELLED: We report on a 9-year-old boy with the hyper-IgM syndrome who presented with rapid impairment of consciousness. The brain CT scan showed multiple round lucencies, and the brain histology revealed necrotizing toxoplasmic encephalitis. This patient, whose CD40/CD40 ligand system was impaired, indicates the importance of this system for defence against toxoplasmic infection. CONCLUSION: Although disseminated toxoplasmosis is a rare complication of the hyper-IgM syndrome, it must be included in the differential diagnosis of infections.
UNLABELLED: We report on a 9-year-old boy with the hyper-IgM syndrome who presented with rapid impairment of consciousness. The brain CT scan showed multiple round lucencies, and the brain histology revealed necrotizing toxoplasmic encephalitis. This patient, whose CD40/CD40 ligand system was impaired, indicates the importance of this system for defence against toxoplasmic infection. CONCLUSION: Although disseminated toxoplasmosis is a rare complication of the hyper-IgM syndrome, it must be included in the differential diagnosis of infections.
Authors: S Kiani-Alikhan; P F K Yong; K C Gilmour; D Grosse-Kreul; E G Davies; M A A Ibrahim Journal: J Clin Immunol Date: 2011-10-19 Impact factor: 8.317
Authors: Djuro Karanovic; Ian C Michelow; Anthony R Hayward; Suk See DeRavin; Ottavia M Delmonte; Michael E Grigg; Adam Kerry Dobbs; Julie E Niemela; Jennifer Stoddard; Zaid Alhinai; Natasha Rybak; Nancy Hernandez; Stefania Pittaluga; Sergio D Rosenzweig; Gulbu Uzel; Luigi D Notarangelo Journal: Front Immunol Date: 2019-02-14 Impact factor: 7.561
Authors: David H McDermott; Lauren E Heusinkveld; Wadih M Zein; H Nida Sen; Martha M Marquesen; Mark Parta; Sergio D Rosenzweig; Gary A Fahle; Michael D Keller; Henry E Wiley; Philip M Murphy Journal: F1000Res Date: 2019-01-02