PURPOSE: Interictal intervals in pilocarpine-induced chronic epilepsy are characterized by apparent normal electrographic activity and longer sleep periods or drowsiness or both. Sparse information exists concerning the neural network activity during these seizure-free intervals. In our research, a [14C]2-deoxy-D-glucose (2DG) autoradiographic technique was used to investigate interictal changes in the metabolism of the epileptic rat brain. METHODS: Epileptic rats were monitored by video-EEG for approximately 120 days, with [14C]2DG injected after a seizure-free interval of > or = 24 h. RESULTS: Autoradiographic analysis revealed an increase in glucose utilization by several brain regions; the most consistent increase was found in the lateral posterior thalamic nucleus and pretectal region. CONCLUSIONS: These findings suggest that the lateral posterior thalamic nucleus and the pretectal region may be involved in cerebral circuits inhibiting epileptic activity during interictal intervals.
PURPOSE: Interictal intervals in pilocarpine-induced chronic epilepsy are characterized by apparent normal electrographic activity and longer sleep periods or drowsiness or both. Sparse information exists concerning the neural network activity during these seizure-free intervals. In our research, a [14C]2-deoxy-D-glucose (2DG) autoradiographic technique was used to investigate interictal changes in the metabolism of the epilepticrat brain. METHODS:Epilepticrats were monitored by video-EEG for approximately 120 days, with [14C]2DG injected after a seizure-free interval of > or = 24 h. RESULTS: Autoradiographic analysis revealed an increase in glucose utilization by several brain regions; the most consistent increase was found in the lateral posterior thalamic nucleus and pretectal region. CONCLUSIONS: These findings suggest that the lateral posterior thalamic nucleus and the pretectal region may be involved in cerebral circuits inhibiting epileptic activity during interictal intervals.
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