| Literature DB >> 9774260 |
B Nicol1, D G Lambert, D J Rowbotham, E Okuda-Ashitaka, S Ito, D Smart, A T McKnight.
Abstract
We have examined the effects of the recently described heptadecapeptide nocistatin on K+-evoked glutamate release from rat cerebrocortical slices in vitro. In vivo, nocistatin reverses the action of nociceptin. Nocistatin (100 nM, n = 7) did not inhibit K+-evoked glutamate release alone. Nociceptin (100 nM) inhibited glutamate release by 51.7 +/- 8.3% (P < 0.05, n = 6) and this was fully reversed by nocistatin (100 nM). Nocistatin also appears to be an antagonist of nociceptin action in vitro.Entities:
Mesh：
Substances：
Year: 1998 PMID： 9774260 DOI： 10.1016/s0014-2999(98)00545-7
Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432