Literature DB >> 97726

Antipunishment effects of diazepam: interaction with shock and food deprivation levels in pigs.

R Dantzer.   

Abstract

The effects of 1mg/kg diazepam on punished behaviour of pigs were investigated under various degrees, of food deprivation and/or shock level. Responses emitted during the punishment signal were affected more by the shock level than by the degree of food deprivation while nonpunished response rates were modified by neither factor. Diazepam treatment increased the number of responses emitted during the punishment signal but interacted with the shock intensity: drug effects were attenuated when the shock intensity was severe, in spite of an equivalent control baseline. Diazepam also increased the overall rate of nonpunished responding. The drug treatment had no reliable effect on flinch and escape thresholds measured in separate experiments. The effects of diazepam on punished responding do not appear to be related to eventual changes in food motivation or sensitivity to electric shock.

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Year:  1978        PMID: 97726     DOI: 10.1007/bf00426797

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN: 0033-3158            Impact factor:   4.530


  17 in total

Review 1.  Behavioral pharmacology and toxicology.

Authors:  G Bignami
Journal:  Annu Rev Pharmacol Toxicol       Date:  1976       Impact factor: 13.820

2.  The effects of chlordiazepoxide and chlorpromazine on a punishment discrimination.

Authors:  I GELLER; J T KULAK; J SEIFTER
Journal:  Psychopharmacologia       Date:  1962-10-31

3.  Comparison between chronic chlordiazepoxide treatment and shock removal in a conflict situation in rats.

Authors:  T O Ts'o; M B Chenoweth
Journal:  Neuropharmacology       Date:  1976-02       Impact factor: 5.250

Review 4.  Behavioral analysis of the effects and mechanisms of action of benzodiazepines.

Authors:  L Cook; J Sepinwall
Journal:  Adv Biochem Psychopharmacol       Date:  1975

5.  Effect of diazepam on performance of pigs in a progressive ratio schedule.

Authors:  R Dantzer
Journal:  Physiol Behav       Date:  1976-07

6.  Tranquilizing effects of diazepam in pigs subjected to a punishment procedure.

Authors:  R Dantzer; M Roca
Journal:  Psychopharmacologia       Date:  1974

Review 7.  Determinants of the specificity of behavioral effects of drugs.

Authors:  R T Kelleher; W H Morse
Journal:  Ergeb Physiol       Date:  1968

8.  Analgesic potency of sodium salicylate, indomethacin, and chlordiazepoxide as measured by the spatial preference technique in the rat.

Authors:  V P Houser; W P Paré
Journal:  Psychopharmacologia       Date:  1973

9.  The alteration of aversive thresholds after chronic administration of two tranquilizing agents.

Authors:  V P Houser
Journal:  Behav Biol       Date:  1974-11

10.  Drugs and punished responding VI: body weight as a determinant of drug effects.

Authors:  D E McMillan
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1976-01
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