| Literature DB >> 9771750 |
A R Brooks-Kayal1, M D Shumate, H Jin, T Y Rikhter, D A Coulter.
Abstract
Temporal lobe epilepsy is the most prevalent seizure disorder in adults. Compromised inhibitory neurotransmitter function in the hippocampus contributes to the hyperexcitability generating this condition, but the underlying molecular mechanisms are unknown. Combining patch-clamp recording and single-cell mRNA amplification (aRNA) techniques in single dentate granule cells, we demonstrate that expression of GABA(A) receptor subunit mRNAs is substantially altered in neurons from epileptic rats. These changes in gene expression precede epilepsy onset by weeks and correlate with profound alterations in receptor function, indicating that aberrant GABA(A) receptor expression and function has an essential role in the process of epileptogenesis.Entities:
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Year: 1998 PMID： 9771750 DOI： 10.1038/2661
Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440