Literature DB >> 9771700

The premature ageing syndrome protein, WRN, is a 3'-->5' exonuclease.

S Huang, B Li, M D Gray, J Oshima, I S Mian, J Campisi.   

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Year:  1998        PMID： 9771700      PMCID： PMC4940158          DOI： 10.1038/2410

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


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  14 in total

1.  Homologous recombination is elevated in some Werner-like syndromes but not during normal in vitro or in vivo senescence of mammalian cells.

Authors:  R Z Cheng; S Murano; B Kurz; R J Shmookler Reis
Journal:  Mutat Res       Date:  1990 Sep-Nov       Impact factor: 2.433

2.  Positionally cloned human disease genes: patterns of evolutionary conservation and functional motifs.

Authors:  A R Mushegian; D E Bassett; M S Boguski; P Bork; E V Koonin
Journal:  Proc Natl Acad Sci U S A       Date:  1997-05-27       Impact factor: 11.205

3.  Positional cloning of the Werner's syndrome gene.

Authors:  C E Yu; J Oshima; Y H Fu; E M Wijsman; F Hisama; R Alisch; S Matthews; J Nakura; T Miki; S Ouais; G M Martin; J Mulligan; G D Schellenberg
Journal:  Science       Date:  1996-04-12       Impact factor: 47.728

4.  Growth characteristics of Werner syndrome cells in vitro.

Authors:  D Salk; E Bryant; H Hoehn; P Johnston; G M Martin
Journal:  Adv Exp Med Biol       Date:  1985       Impact factor: 2.622

5.  The Werner syndrome protein is a DNA helicase.

Authors:  M D Gray; J C Shen; A S Kamath-Loeb; A Blank; B L Sopher; G M Martin; J Oshima; L A Loeb
Journal:  Nat Genet       Date:  1997-09       Impact factor: 38.330

6.  Hierarchical deterioration of body systems in Werner's syndrome: implications for normal ageing.

Authors:  M Goto
Journal:  Mech Ageing Dev       Date:  1997-12       Impact factor: 5.432

7.  Bloom syndrome: a mendelian prototype of somatic mutational disease.

Authors:  J German
Journal:  Medicine (Baltimore)       Date:  1993-11       Impact factor: 1.889

8.  Replicative life-span of cultivated human cells. Effects of donor's age, tissue, and genotype.

Authors:  G M Martin; C A Sprague; C J Epstein
Journal:  Lab Invest       Date:  1970-07       Impact factor: 5.662

9.  Replication focus-forming activity 1 and the Werner syndrome gene product.

Authors:  H Yan; C Y Chen; R Kobayashi; J Newport
Journal:  Nat Genet       Date:  1998-08       Impact factor: 38.330

10.  Mutator phenotype of Werner syndrome is characterized by extensive deletions.

Authors:  K Fukuchi; G M Martin; R J Monnat
Journal:  Proc Natl Acad Sci U S A       Date:  1989-08       Impact factor: 11.205
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  142 in total

1.  p53-mediated apoptosis is attenuated in Werner syndrome cells.

Authors:  E A Spillare; A I Robles; X W Wang; J C Shen; C E Yu; G D Schellenberg; C C Harris
Journal:  Genes Dev       Date:  1999-06-01       Impact factor: 11.361

2.  A functional interaction of Ku with Werner exonuclease facilitates digestion of damaged DNA.

Authors:  D K Orren; A Machwe; P Karmakar; J Piotrowski; M P Cooper; V A Bohr
Journal:  Nucleic Acids Res       Date:  2001-05-01       Impact factor: 16.971

3.  The Bloom's syndrome gene product promotes branch migration of holliday junctions.

Authors:  J K Karow; A Constantinou; J L Li; S C West; I D Hickson
Journal:  Proc Natl Acad Sci U S A       Date:  2000-06-06       Impact factor: 11.205

4.  Ku complex interacts with and stimulates the Werner protein.

Authors:  M P Cooper; A Machwe; D K Orren; R M Brosh; D Ramsden; V A Bohr
Journal:  Genes Dev       Date:  2000-04-15       Impact factor: 11.361

5.  Potent inhibition of werner and bloom helicases by DNA minor groove binding drugs.

Authors:  R M Brosh; J K Karow; E J White; N D Shaw; I D Hickson; V A Bohr
Journal:  Nucleic Acids Res       Date:  2000-06-15       Impact factor: 16.971

6.  The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases.

Authors:  P Mohaghegh; J K Karow; R M Brosh; V A Bohr; I D Hickson
Journal:  Nucleic Acids Res       Date:  2001-07-01       Impact factor: 16.971

7.  Werner's syndrome protein is required for correct recovery after replication arrest and DNA damage induced in S-phase of cell cycle.

Authors:  P Pichierri; A Franchitto; P Mosesso; F Palitti
Journal:  Mol Biol Cell       Date:  2001-08       Impact factor: 4.138

8.  Telomere repeat DNA forms a large non-covalent complex with unique cohesive properties which is dissociated by Werner syndrome DNA helicase in the presence of replication protein A.

Authors:  I Ohsugi; Y Tokutake; N Suzuki; T Ide; M Sugimoto; Y Furuichi
Journal:  Nucleic Acids Res       Date:  2000-09-15       Impact factor: 16.971

9.  Werner syndrome exonuclease catalyzes structure-dependent degradation of DNA.

Authors:  J C Shen; L A Loeb
Journal:  Nucleic Acids Res       Date:  2000-09-01       Impact factor: 16.971

10.  Werner protein recruits DNA polymerase delta to the nucleolus.

Authors:  A M Szekely; Y H Chen; C Zhang; J Oshima; S M Weissman
Journal:  Proc Natl Acad Sci U S A       Date:  2000-10-10       Impact factor: 11.205
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