Literature DB >> 9771180

The management of metformin overdose.

K F Teale1, A Devine, H Stewart, N J Harper.   

Abstract

Only two cases of deliberate self-poisoning with metformin have been described in the literature. We report the management of three cases, all of which presented with severe lactic acidosis. Two cases had a fatal outcome. The options for treatment and previous cases reported in the literature are reviewed. Recommendations for the management of metformin overdose include early recognition, intensive support of the cardiovascular system, the correction of metabolic acidosis and the maintenance of body temperature. The use of venovenous haemofiltration against a non-lactate containing fluid may improve outcome when sodium bicarbonate alone fails to reverse severe systemic acidosis.

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Year:  1998        PMID： 9771180     DOI： 10.1046/j.1365-2044.1998.436-az0549.x

Source DB:  PubMed          Journal:  Anaesthesia        ISSN： 0003-2409            Impact factor:   6.955


  14 in total

1.  Severe metformin intoxication with lactic acidosis in an adolescent.

Authors:  Martin Lacher; Maren Hermanns-Clausen; Karsten Haeffner; Matthias Brandis; Martin Pohl
Journal:  Eur J Pediatr       Date:  2005-02-24       Impact factor: 3.183

2.  Toxicology case of the month: oral hypoglycaemic overdose.

Authors:  J Soderstrom; L Murray; F F S Daly; M Little
Journal:  Emerg Med J       Date:  2006-07       Impact factor: 2.740

3.  Case Files from the University of California San Diego Health System Fellowship Coma and Severe Acidosis: Remember to Consider Acetaminophen.

Authors:  Janna H Villano; Charles W O'Connell; Binh T Ly; Aaron Schneir
Journal:  J Med Toxicol       Date:  2015-09

4.  Metformin-related lactic acidosis in patients with acute kidney injury.

Authors:  Vassilios Devetzis; Ploumis Passadakis; Stelios Panagoutsos; Marios Theodoridis; Elias Thodis; Anastasia Georgoulidou; Vassilis Vargemezis
Journal:  Int Urol Nephrol       Date:  2010-09-22       Impact factor: 2.370

Review 5.  Hyperglycaemic crises and lactic acidosis in diabetes mellitus.

Authors:  P English; G Williams
Journal:  Postgrad Med J       Date:  2004-05       Impact factor: 2.401

6.  [Lactic acidosis and acute abdomen from biguanide intoxication].

Authors:  O Moerer; J Barwing; P Neumann
Journal:  Anaesthesist       Date:  2004-02       Impact factor: 1.041

7.  Extracorporeal treatment with high-volume continuous venovenous hemodiafiltration and charcoal-based sorbent hemoperfusion for severe metformin-associated lactic acidosis.

Authors:  Suneel Kumar Garg; Omender Singh; Desh Deepak; Akhilesh Singh; Rohit Yadav; Kirti Vashist
Journal:  Indian J Crit Care Med       Date:  2016-05

8.  Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1.

Authors:  Brian Onken; Monica Driscoll
Journal:  PLoS One       Date:  2010-01-18       Impact factor: 3.240

9.  Metformin-induced lactic acidosis: a case series.

Authors:  Joana Silvestre; Susana Carvalho; Vitor Mendes; Luis Coelho; Camila Tapadinhas; Pedro Ferreira; Pedro Povoa; Fatima Ceia
Journal:  J Med Case Rep       Date:  2007-10-31

10.  Metformin-Associated Lactic Acidosis following Intentional Overdose Successfully Treated with Tris-Hydroxymethyl Aminomethane and Renal Replacement Therapy.

Authors:  Ngan Lam; Gurbir Sekhon; Andrew A House
Journal:  Case Rep Nephrol       Date:  2012-05-23
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