Literature DB >> 9770434

Varicella-zoster virus ORF57, unlike its pseudorabies virus UL3.5 homolog, is dispensable for viral replication in cell culture.

E Cox1, S Reddy, I Iofin, J I Cohen.   

Abstract

Varicella zoster virus (VZV) encodes five genes that do not have homologs in herpes simplex virus. One of these genes, VZV ORF57, is predicted to encode a protein containing 71 amino acids. Antibody to ORF57 protein immunoprecipitated a 6-kDa protein in the cytosol of VZV-infected cells. Although the homolog of VZV ORF57 in pseudorabies virus, UL3.5, is critical for viral egress and growth in cell culture, VZV unable to express ORF57 replicated to titers similar to those seen with parental virus. Thus VZV ORF57 has a different role in viral replication than its pseudorabies virus homolog.

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Year:  1998        PMID： 9770434     DOI： 10.1006/viro.1998.9349

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.513


  15 in total

1.  Infection of human T lymphocytes with varicella-zoster virus: an analysis with viral mutants and clinical isolates.

Authors:  W Soong; J C Schultz; A C Patera; M H Sommer; J I Cohen
Journal:  J Virol       Date:  2000-02       Impact factor: 5.103

2.  Bovine herpesvirus 1 U(L)3.5 interacts with bovine herpesvirus 1 alpha-transinducing factor.

Authors:  N Lam; G J Letchworth
Journal:  J Virol       Date:  2000-03       Impact factor: 5.103

3.  Varicella-zoster virus open reading frame 2 encodes a membrane phosphoprotein that is dispensable for viral replication and for establishment of latency.

Authors:  Hitoshi Sato; Lesley Pesnicak; Jeffrey I Cohen
Journal:  J Virol       Date:  2002-04       Impact factor: 5.103

Review 4.  The varicella-zoster virus genome.

Authors:  Jeffrey I Cohen
Journal:  Curr Top Microbiol Immunol       Date:  2010       Impact factor: 4.291

Review 5.  Rodent models of varicella-zoster virus neurotropism.

Authors:  Jeffrey I Cohen
Journal:  Curr Top Microbiol Immunol       Date:  2010       Impact factor: 4.291

6.  Varicella-zoster virus ORF47 protein kinase, which is required for replication in human T cells, and ORF66 protein kinase, which is expressed during latency, are dispensable for establishment of latency.

Authors:  Hitoshi Sato; Lesley Pesnicak; Jeffrey I Cohen
Journal:  J Virol       Date:  2003-10       Impact factor: 5.103

7.  Array analysis of viral gene transcription during lytic infection of cells in tissue culture with Varicella-Zoster virus.

Authors:  Randall J Cohrs; Michael P Hurley; Donald H Gilden
Journal:  J Virol       Date:  2003-11       Impact factor: 5.103

8.  Genome-wide mutagenesis reveals that ORF7 is a novel VZV skin-tropic factor.

Authors:  Zhen Zhang; Anca Selariu; Charles Warden; Grace Huang; Ying Huang; Oluleke Zaccheus; Tong Cheng; Ningshao Xia; Hua Zhu
Journal:  PLoS Pathog       Date:  2010-07-01       Impact factor: 6.823

9.  Comprehensive analysis of varicella-zoster virus proteins using a new monoclonal antibody collection.

Authors:  Tihana Lenac Roviš; Susanne M Bailer; Venkata R Pothineni; Werner J D Ouwendijk; Hrvoje Šimić; Marina Babić; Karmela Miklić; Suzana Malić; Marieke C Verweij; Armin Baiker; Orland Gonzalez; Albrecht von Brunn; Ralf Zimmer; Klaus Früh; Georges M G M Verjans; Stipan Jonjić; Jürgen Haas
Journal:  J Virol       Date:  2013-04-17       Impact factor: 5.103

10.  Relevance of the interaction between alphaherpesvirus UL3.5 and UL48 proteins for virion maturation and neuroinvasion.

Authors:  Walter Fuchs; Harald Granzow; Barbara G Klupp; Axel Karger; Kathrin Michael; Christina Maresch; Robert Klopfleisch; Thomas C Mettenleiter
Journal:  J Virol       Date:  2007-06-20       Impact factor: 5.103
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