PURPOSE: To assess the use of corneal topography in conjunction with slitlamp biomicroscopy and retinoscopy to diagnose keratoconus in a large group of patients with Ehlers-Danlos syndrome (EDS). SETTING: Kresge Eye Institute, Wayne State University, Detroit, Michigan, USA. METHODS: Thirty-six patients (72 eyes) with genetically typed EDS had slitlamp biomicroscopy, retinoscopy, and videokeratography with the EyeSys instrument. The presence or absence of slitlamp keratoconus findings was correlated to a presumptive diagnosis based on corneal topography using derived topographic indexes associated with keratoconus. These topographic indexes included central corneal power, (CCP), difference in CCP, inferosuperior asymmetry (I-S) value, and asphericity (Q). Axial and profile difference maps were generated and analyzed for findings suggestive of keratoconus. RESULTS: In 72 eyes, no keratoconus was found using slitlamp biomicroscopy. No eye had an I-S value greater than 1.60 diopters (D), 2 eyes had a CCP greater than 46.50 D, and 2 eyes had a Q value less than -1.00. Eight of 36 pairs of eyes had an intereye CCP greater than 0.92 D. In both eyes of the patient with Q values less than -1.00 the profile difference maps were mildly abnormal. CONCLUSIONS: Slitlamp biomicroscopy of the cornea was unremarkable in all patients. Only 1 patient had Q values and profile difference maps that were mildly suggestive of keratoconus. Even after adding topography to the examination, it appears that keratoconus in a known population of patients with EDS remains rare.
PURPOSE: To assess the use of corneal topography in conjunction with slitlamp biomicroscopy and retinoscopy to diagnose keratoconus in a large group of patients with Ehlers-Danlos syndrome (EDS). SETTING: Kresge Eye Institute, Wayne State University, Detroit, Michigan, USA. METHODS: Thirty-six patients (72 eyes) with genetically typed EDS had slitlamp biomicroscopy, retinoscopy, and videokeratography with the EyeSys instrument. The presence or absence of slitlamp keratoconus findings was correlated to a presumptive diagnosis based on corneal topography using derived topographic indexes associated with keratoconus. These topographic indexes included central corneal power, (CCP), difference in CCP, inferosuperior asymmetry (I-S) value, and asphericity (Q). Axial and profile difference maps were generated and analyzed for findings suggestive of keratoconus. RESULTS: In 72 eyes, no keratoconus was found using slitlamp biomicroscopy. No eye had an I-S value greater than 1.60 diopters (D), 2 eyes had a CCP greater than 46.50 D, and 2 eyes had a Q value less than -1.00. Eight of 36 pairs of eyes had an intereye CCP greater than 0.92 D. In both eyes of the patient with Q values less than -1.00 the profile difference maps were mildly abnormal. CONCLUSIONS: Slitlamp biomicroscopy of the cornea was unremarkable in all patients. Only 1 patient had Q values and profile difference maps that were mildly suggestive of keratoconus. Even after adding topography to the examination, it appears that keratoconus in a known population of patients with EDS remains rare.
Authors: Dimitrios Karamichos; Paulina Escandon; Brenda Vasini; Sarah E Nicholas; Lyly Van; Deanna H Dang; Rebecca L Cunningham; Kamran M Riaz Journal: Prog Retin Eye Res Date: 2021-11-02 Impact factor: 19.704
Authors: Grant C Hopping; Anisha N Somani; Uma Vaidyanathan; Harry Liu; James R Barnes; Yasmyne C Ronquillo; Phillip C Hoopes; Majid Moshirfar Journal: Am J Ophthalmol Case Rep Date: 2020-05-04
Authors: Samuel Asanad; May Bayomi; Douglas Brown; Joshua Buzzard; Eric Lai; Carlthan Ling; Trisha Miglani; Taariq Mohammed; Joby Tsai; Olivia Uddin; Eric Singman Journal: Front Med (Lausanne) Date: 2022-09-27