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Literature DB >> 9767181

An increase in [3H] CGS21680 binding in the striatum of postmortem brains of chronic schizophrenics.

Abstract

We measured adenosine 2a receptors in basal ganglia of 13 schizophrenics and 10 controls, using [3H] CGS21680 as a ligand for the receptor binding assay. There was a significant increase in the specific [3H] CGS21680 binding in the putamen and caudate, but not in the globus pallidus of externa, of the schizophrenic patients, compared to those of controls. These results provide evidence suggesting that adenosine 2a receptors play a role in the pathophysiology of schizophrenia. Copyright 1998 Elsevier Science B. V.

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Year: 1998 PMID： 9767181 DOI： 10.1016/s0006-8993(98)00840-3

Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252

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Cited

13 in total

Review 1. Adenosine hypothesis of schizophrenia--opportunities for pharmacotherapy.

Authors: Detlev Boison; Philipp Singer; Hai-Ying Shen; Joram Feldon; Benjamin K Yee
Journal: Neuropharmacology Date: 2011-02-17 Impact factor: 5.250

2. Deletion of striatal adenosine A(2A) receptor spares latent inhibition and prepulse inhibition but impairs active avoidance learning.

Authors: Philipp Singer; Catherine J Wei; Jiang-Fan Chen; Detlev Boison; Benjamin K Yee
Journal: Behav Brain Res Date: 2012-12-28 Impact factor: 3.332

3. Adenosine Kinase Expression in the Frontal Cortex in Schizophrenia.

Authors: Cassidy L Moody; Adam J Funk; Emily Devine; Ryan C Devore Homan; Detlev Boison; Robert E McCullumsmith; Sinead M O'Donovan
Journal: Schizophr Bull Date: 2020-04-10 Impact factor: 9.306

4. Upregulation of adenosine A2A receptors induced by atypical antipsychotics and its correlation with sensory gating in schizophrenia patients.

Authors: Jie Zhang; Chadi G Abdallah; Junqing Wang; Xiaona Wan; Chunlian Liang; Liyun Jiang; Yuzhen Liu; Haixing Huang; Xiaohong Hong; Qingjun Huang; Renhua Wu; Chongtao Xu
Journal: Psychiatry Res Date: 2012-06-16 Impact factor: 3.222

5. Deletion of adenosine A2A receptors from astrocytes disrupts glutamate homeostasis leading to psychomotor and cognitive impairment: relevance to schizophrenia.

Authors: Marco Matos; Hai-Ying Shen; Elisabete Augusto; Yumei Wang; Catherine J Wei; Yu Tian Wang; Paula Agostinho; Detlev Boison; Rodrigo A Cunha; Jiang-Fan Chen
Journal: Biol Psychiatry Date: 2015-02-27 Impact factor: 13.382

6. Subchronic treatment with methamphetamine and phencyclidine differentially alters the adenosine A1 and A2A receptors in the prefrontal cortex, hippocampus, and striatum of the rat.

Authors: Y Shirayama; K Hashimoto; T Higuchi; Y Minabe
Journal: Neurochem Res Date: 2001-04 Impact factor: 3.996

An increase in [3H] CGS21680 binding in the striatum of postmortem brains of chronic schizophrenics.

Review 1. Adenosine hypothesis of schizophrenia--opportunities for pharmacotherapy.

2. Deletion of striatal adenosine A(2A) receptor spares latent inhibition and prepulse inhibition but impairs active avoidance learning.

3. Adenosine Kinase Expression in the Frontal Cortex in Schizophrenia.

4. Upregulation of adenosine A2A receptors induced by atypical antipsychotics and its correlation with sensory gating in schizophrenia patients.

5. Deletion of adenosine A2A receptors from astrocytes disrupts glutamate homeostasis leading to psychomotor and cognitive impairment: relevance to schizophrenia.

6. Subchronic treatment with methamphetamine and phencyclidine differentially alters the adenosine A1 and A2A receptors in the prefrontal cortex, hippocampus, and striatum of the rat.

Review 7. Modulators of nucleoside metabolism in the therapy of brain diseases.

Review 8. Potential therapeutic interest of adenosine A2A receptors in psychiatric disorders.

9. Cell-subtype-specific changes in adenosine pathways in schizophrenia.

10. Adenosine A_2A receptor in schizophrenia: an in vivo brain PET imaging study.