Y Kusanagi1, H Ochi, K Matsubara, M Ito. 1. Department of Obstetrics and Gynecology, Ehime University School of Medicine, Shigenobu, Japan.
Abstract
BACKGROUND: Hypereosinophilic syndrome is characterized by peripheral blood eosinophilia and multiple organ system involvement. Only one case in a newborn has been reported. CASE: Fetal sonography performed on a 33-year-old woman at 35 weeks' gestation showed pericardial effusion and cardiomegaly. The infant was delivered by cesarean at 35 weeks' gestation because of a worsening of the pericardial effusion. Hematologic studies revealed unexplained hypereosinophilia, and the pericardial fluid contained a large number of eosinophils. Chromosomal analysis revealed trisomy 21. The hypereosinophilia, pericardial effusion, and cardiomegaly all resolved after 8 weeks of steroid therapy. CONCLUSION: Hypereosinophilic syndrome caused pericardial effusion and cardiomegaly in a fetus with trisomy 21.
BACKGROUND:Hypereosinophilic syndrome is characterized by peripheral blood eosinophilia and multiple organ system involvement. Only one case in a newborn has been reported. CASE: Fetal sonography performed on a 33-year-old woman at 35 weeks' gestation showed pericardial effusion and cardiomegaly. The infant was delivered by cesarean at 35 weeks' gestation because of a worsening of the pericardial effusion. Hematologic studies revealed unexplained hypereosinophilia, and the pericardial fluid contained a large number of eosinophils. Chromosomal analysis revealed trisomy 21. The hypereosinophilia, pericardial effusion, and cardiomegaly all resolved after 8 weeks of steroid therapy. CONCLUSION:Hypereosinophilic syndrome caused pericardial effusion and cardiomegaly in a fetus with trisomy 21.
Authors: Yong Jun Yang; Adam J Macneil; Robert Junkins; Svetlana O Carrigan; Jin-Tian Tang; Nicholas Forward; David Hoskin; Jason N Berman; Tong-Jun Lin Journal: Am J Pathol Date: 2011-07-08 Impact factor: 4.307