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Literature DB >> 976437

The effect of sulfhydryl reagents upon the activity of 40S ribosomal subunits.

Abstract

p-Chloromercuribenzoate inhibited the poly (U)-dependent binding of the Phe-tRNA to the 40S ribosomal subunit but displayed no inhibitory effect on the binding of poly (U) to the ribosome. Other sulfhydryl reagents tested, like N-ethylmaleimide and iodoacetamide, did not affect the binding of Phe-tRNA to the small ribosomal subunit.

Entities: Chemical

Mesh：

Substances：

Year: 1976 PMID： 976437 DOI： 10.1007/BF01953087

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

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References

11 in total

1. Ribosomal protein S12 and 'non-enzymatic' translocation.

Authors: L P Gavrilova; V E Koteliansky; A S Spirin
Journal: FEBS Lett Date: 1974-09-01 Impact factor: 4.124

2. Inactivation of human ribosomes by N-ethylmaleimide.

Authors: H Mönkemeyer; E Bermek
Journal: Hoppe Seylers Z Physiol Chem Date: 1974-01

3. Changes in the number of N-ethylmaleimide-reacting sulfhydryl groups resulting from ribosomal subunit interactions.

Authors: R D Nolan; P Tailleur
Journal: Biochim Biophys Acta Date: 1974-11-20

4. A protein fraction of the 60 S subunit from reticulocyte ribosomes associated with acceptor-site binding activity.

Authors: T C Cheng; H C McAllister
Journal: J Mol Biol Date: 1973-06-25 Impact factor: 5.469

5. Mechanisms in protein synthesis. XII. Sites of action of showdomycin in a cell-free polyphenylalanine synthesizing system from human lymphatic tissue: ribosomes and elongation factor TF II.

Authors: E Bermek; W Krämer; H Mönkemeyer; H Matthaei
Journal: Biochem Biophys Res Commun Date: 1970-09-30 Impact factor: 3.575

The effect of sulfhydryl reagents upon the activity of 40S ribosomal subunits.

1. Ribosomal protein S12 and 'non-enzymatic' translocation.

2. Inactivation of human ribosomes by N-ethylmaleimide.

3. Changes in the number of N-ethylmaleimide-reacting sulfhydryl groups resulting from ribosomal subunit interactions.

4. A protein fraction of the 60 S subunit from reticulocyte ribosomes associated with acceptor-site binding activity.

5. Mechanisms in protein synthesis. XII. Sites of action of showdomycin in a cell-free polyphenylalanine synthesizing system from human lymphatic tissue: ribosomes and elongation factor TF II.

6. Evidence for disulfide interaction in situ between two adjacent proteins in mammalian 60-S ribosomal subunits.

7. The role of SH-groups of human ribosomal subunits in polypeptide synthesis.

8. Specificity of mammalian transferase II binding to ribosomes.

9. Involvement of sulfhydryl groups in the binding of tRNA to reticulocyte ribosomes.

10. Formation and function of the active ribosome complex.