Literature DB >> 9763625

Thiophosphorylation of myosin light chain increases rigor stiffness of rabbit smooth muscle.

A S Khromov1, A V Somlyo, A P Somlyo.   

Abstract

1. The effect of thiophosphorylation of the regulatory myosin light chain (MLC20) on rigor stiffness was determined in permeabilized rabbit bladder smooth muscle. 2. Rigor stiffness of alpha-toxin-permeabilized smooth muscle was significantly increased by thiophosphorylation of MLC20. This increase may have been due to partial shortening (melting) in the proximal rod region and/or stiffening of the regulatory domain of the myosin head. 3. We suggest that phosphorylation of MLC20, by increasing the stiffness of the S1 lever arm and/or S2 hinge regions of the myosin molecule, favours separation of the two phosphorylated heads and consequent deinhibition of motor domain activity.

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Year:  1998        PMID： 9763625      PMCID： PMC2231214          DOI： 10.1111/j.1469-7793.1998.345be.x

Source DB:  PubMed          Journal:  J Physiol        ISSN： 0022-3751            Impact factor:   5.182


  26 in total

1.  The stiffness of skeletal muscle in isometric contraction and rigor: the fraction of myosin heads bound to actin.

Authors:  M Linari; I Dobbie; M Reconditi; N Koubassova; M Irving; G Piazzesi; V Lombardi
Journal:  Biophys J       Date:  1998-05       Impact factor: 4.033

Review 2.  The mechanism of muscular contraction.

Authors:  H E Huxley
Journal:  Science       Date:  1969-06-20       Impact factor: 47.728

3.  The apparently negatively cooperative phosphorylation of smooth muscle myosin at low ionic strength is related to its filamentous state.

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Journal:  J Biol Chem       Date:  1983-12-10       Impact factor: 5.157

4.  The anatomical location of the series elastic component in rat vascular smooth muscle.

Authors:  M J Mulvany; D M Warshaw
Journal:  J Physiol       Date:  1981-05       Impact factor: 5.182

5.  Length dependence of calcium activated isometric force and immediate stiffness in living and glycerol extracted vascular smooth muscle.

Authors:  G Pfitzer; J W Peterson; J C Rüegg
Journal:  Pflugers Arch       Date:  1982-08       Impact factor: 3.657

6.  The effects of MgADP on cross-bridge kinetics: a laser flash photolysis study of guinea-pig smooth muscle.

Authors:  E Nishiye; A V Somlyo; K Török; A P Somlyo
Journal:  J Physiol       Date:  1993-01       Impact factor: 5.182

7.  Cross-bridge kinetics, cooperativity, and negatively strained cross-bridges in vertebrate smooth muscle. A laser-flash photolysis study.

Authors:  A V Somlyo; Y E Goldman; T Fujimori; M Bond; D R Trentham; A P Somlyo
Journal:  J Gen Physiol       Date:  1988-02       Impact factor: 4.086

8.  Force response to rapid length change during contraction and rigor in skinned smooth muscle of guinea-pig taenia coli.

Authors:  H Arheden; P Hellstrand
Journal:  J Physiol       Date:  1991-10       Impact factor: 5.182

9.  Cross-bridge elasticity in single smooth muscle cells.

Authors:  D M Warshaw; F S Fay
Journal:  J Gen Physiol       Date:  1983-08       Impact factor: 4.086

Review 10.  Characterization of cross-bridge elasticity and kinetics of cross-bridge cycling during force development in single smooth muscle cells.

Authors:  D M Warshaw; D D Rees; F S Fay
Journal:  J Gen Physiol       Date:  1988-06       Impact factor: 4.086
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  10 in total

1.  Modification of interface between regulatory and essential light chains hampers phosphorylation-dependent activation of smooth muscle myosin.

Authors:  Shaowei Ni; Feng Hong; Brian D Haldeman; Josh E Baker; Kevin C Facemyer; Christine R Cremo
Journal:  J Biol Chem       Date:  2012-05-01       Impact factor: 5.157

2.  The molecular effects of skeletal muscle myosin regulatory light chain phosphorylation.

Authors:  Michael J Greenberg; Tanya R Mealy; James D Watt; Michelle Jones; Danuta Szczesna-Cordary; Jeffrey R Moore
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2009-05-20       Impact factor: 3.619

3.  Cardiac myosin light chain phosphorylation and inotropic effects of a biased ligand, TRV120023, in a dilated cardiomyopathy model.

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Journal:  Cardiovasc Res       Date:  2015-06-04       Impact factor: 10.787

4.  Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease.

Authors:  Farah Sheikh; Kunfu Ouyang; Stuart G Campbell; Robert C Lyon; Joyce Chuang; Dan Fitzsimons; Jared Tangney; Carlos G Hidalgo; Charles S Chung; Hongqiang Cheng; Nancy D Dalton; Yusu Gu; Hideko Kasahara; Majid Ghassemian; Jeffrey H Omens; Kirk L Peterson; Henk L Granzier; Richard L Moss; Andrew D McCulloch; Ju Chen
Journal:  J Clin Invest       Date:  2012-03-19       Impact factor: 14.808

5.  Photolytic release of MgADP reduces rigor force in smooth muscle.

Authors:  A S Khromov; A P Somlyo; A V Somlyo
Journal:  Biophys J       Date:  2001-04       Impact factor: 4.033

6.  Impact of familial hypertrophic cardiomyopathy-linked mutations in the NH2 terminus of the RLC on β-myosin cross-bridge mechanics.

Authors:  Gerrie P Farman; Priya Muthu; Katarzyna Kazmierczak; Danuta Szczesna-Cordary; Jeffrey R Moore
Journal:  J Appl Physiol (1985)       Date:  2014-10-16

Review 7.  Getting the skinny on thick filament regulation in cardiac muscle biology and disease.

Authors:  Farah Sheikh; Robert C Lyon; Ju Chen
Journal:  Trends Cardiovasc Med       Date:  2013-08-19       Impact factor: 6.677

Review 8.  Smooth muscle myosin: regulation and properties.

Authors:  Avril V Somlyo; Alexander S Khromov; Martin R Webb; Michael A Ferenczi; David R Trentham; Zhen-He He; Sitong Sheng; Zhifeng Shao; Andrew P Somlyo
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2004-12-29       Impact factor: 6.237

9.  Myosin light chain phosphorylation enhances contraction of heart muscle via structural changes in both thick and thin filaments.

Authors:  Thomas Kampourakis; Yin-Biao Sun; Malcolm Irving
Journal:  Proc Natl Acad Sci U S A       Date:  2016-05-09       Impact factor: 11.205

10.  Myosin regulatory light chain (RLC) phosphorylation change as a modulator of cardiac muscle contraction in disease.

Authors:  Christopher Toepfer; Valentina Caorsi; Thomas Kampourakis; Markus B Sikkel; Timothy G West; Man-Ching Leung; Sara A Al-Saud; Kenneth T MacLeod; Alexander R Lyon; Steven B Marston; James R Sellers; Michael A Ferenczi
Journal:  J Biol Chem       Date:  2013-03-25       Impact factor: 5.157
  10 in total

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