Literature DB >> 9762914

Intestinal lactase-phlorizin hydrolase (LPH): the two catalytic sites; the role of the pancreas in pro-LPH maturation.

L Zecca1, J E Mesonero, A Stutz, J C Poirée, J Giudicelli, R Cursio, S M Gloor, G Semenza.   

Abstract

Brush border lactase-phlorizin hydrolase carries two catalytic sites. In the human enzyme lactase comprises Glu-1749, phlorizin hydrolase Glu-1273. The proteolytic processing of pro-lactase-phlorizin hydrolase by (rat) enterocytes stops two amino acid residues short of the N-terminus of 'mature' final, brush border lactase-phlorizin hydrolase. Only these two amino acid residues are removed by luminal pancreatic protease(s), probably trypsin.

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Year:  1998        PMID： 9762914     DOI： 10.1016/s0014-5793(98)01076-x

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  13 in total

1.  Partial amino acid sequence and mRNA analysis of cytosolic pyridoxine-beta-D-glucoside hydrolase from porcine intestinal mucosa: proposed derivation from the lactase-phlorizin hydrolase gene.

Authors:  Chi-Wah Tseung; Laura G McMahon; Jorge Vázquez; Jan Pohl; Jesse F Gregory
Journal:  Biochem J       Date:  2004-05-15       Impact factor: 3.857

Review 2.  Current and Novel Aspects on the Non-lysosomal β-Glucosylceramidase GBA2.

Authors:  Aureli Massimo; Samarani Maura; Loberto Nicoletta; Mancini Giulia; Murdica Valentina; Chiricozzi Elena; Prinetti Alessandro; Bassi Rosaria; Sonnino Sandro
Journal:  Neurochem Res       Date:  2015-11-24       Impact factor: 3.996

3.  Structural hierarchy of regulatory elements in the folding and transport of an intestinal multidomain protein.

Authors:  Marc Behrendt; Julio Polaina; Hassan Y Naim
Journal:  J Biol Chem       Date:  2009-12-02       Impact factor: 5.157

4.  A sensitive gel-based method combining distinct cyclophellitol-based probes for the identification of acid/base residues in human retaining β-glucosidases.

Authors:  Wouter W Kallemeijn; Martin D Witte; Tineke M Voorn-Brouwer; Marthe T C Walvoort; Kah-Yee Li; Jeroen D C Codée; Gijsbert A van der Marel; Rolf G Boot; Herman S Overkleeft; Johannes M F G Aerts
Journal:  J Biol Chem       Date:  2014-10-24       Impact factor: 5.157

5.  Substrate (aglycone) specificity of human cytosolic beta-glucosidase.

Authors:  Jean-Guy Berrin; Mirjam Czjzek; Paul A Kroon; W Russell McLauchlan; Antoine Puigserver; Gary Williamson; Nathalie Juge
Journal:  Biochem J       Date:  2003-07-01       Impact factor: 3.857

6.  Mutations in the translated region of the lactase gene (LCT) underlie congenital lactase deficiency.

Authors:  Mikko Kuokkanen; Jorma Kokkonen; Nabil Sabri Enattah; Tero Ylisaukko-Oja; Hanna Komu; Teppo Varilo; Leena Peltonen; Erkki Savilahti; Irma Jarvela
Journal:  Am J Hum Genet       Date:  2005-12-15       Impact factor: 11.025

7.  Molecular characterization of a male-specific glycosyl hydrolase, Lma-p72, secreted on to the abdominal surface of the Madeira cockroach Leucophaea maderae (Blaberidae, Oxyhaloinae).

Authors:  Richard Cornette; Jean-Pierre Farine; Dehbia Abed-Viellard; Brigitte Quennedey; Rémy Brossut
Journal:  Biochem J       Date:  2003-06-01       Impact factor: 3.857

Review 8.  Small bowel review: normal physiology part 1.

Authors:  A B Thomson; M Keelan; A Thiesen; M T Clandinin; M Ropeleski; G E Wild
Journal:  Dig Dis Sci       Date:  2001-12       Impact factor: 3.199

9.  Four novel mutations in the lactase gene (LCT) underlying congenital lactase deficiency (CLD).

Authors:  Suvi Torniainen; Roberta Freddara; Taina Routi; Carolien Gijsbers; Carlo Catassi; Pia Höglund; Erkki Savilahti; Irma Järvelä
Journal:  BMC Gastroenterol       Date:  2009-01-22       Impact factor: 3.067

Review 10.  The Diverse Forms of Lactose Intolerance and the Putative Linkage to Several Cancers.

Authors:  Mahdi Amiri; Lena Diekmann; Maren von Köckritz-Blickwede; Hassan Y Naim
Journal:  Nutrients       Date:  2015-08-28       Impact factor: 5.717
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